Activella

Generic name: estradiol and norethindrone

Used for: Hot flashes from menopause · Vaginal dryness from menopause (vaginal atrophy) · Preventing osteoporosis after menopause · 2 more

How do you pay?

How to pay the least

Ask for the cash price

Generic estradiol and norethindrone

No pharmacy we check posts a price for estradiol and norethindrone, 30 tablets.

  1. Ask your pharmacy for the cash price of generic estradiol and norethindrone.Find pharmacies near you 
  2. Ask one or two other pharmacies too. Cash prices for the same generic can differ a lot from store to store.

A regular generic has the same active ingredient as Activella, and the FDA requires it to work the same way.

Compare every option

Question
Brand nameActivella
Authorized genericestradiol and norethindrone
Regular genericestradiol and norethindrone
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Cash priceAsk the pharmacyOften less than Activella
Cash priceAsk the pharmacyUsually the lowest
Same as Activella?
The original
Same medicine
Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Activella’s maker. Ask the pharmacy for Activella’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Activella, without the brand name. Give the pharmacy its NDC to get it.

estradiol and norethindrone

Sold by
  • Amneal PharmaceuticalsThe company behind ActivellaSold under the name Lopreeza
Your strength
NDC to ask for
  • 0.5 mg / 0.1 mgtablet
    • 69238-1252-811-digit: 69238-1252-085 dialpacks of 28 tablets
  • 1 mg / 0.5 mgtablet
    • 69238-1251-811-digit: 69238-1251-085 dialpacks of 28 tablets

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Activella, can you tell me what I’d pay for the brand, for the authorized generic from Amneal Pharmaceuticals, and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

1 mg / 0.5 mg tablet

Same active and inactive ingredients as Activella.

BrandActivella
Authorized genericAmneal Pharmaceuticals
See the ingredients

Active: estradiol 1 mg · norethindrone acetate 0.5 mg

Inactive, on both labels:

  • Copovidone k25-31
  • Hypromelloses
  • Lactose monohydrate
  • Magnesium stearate
  • Corn starch
  • Talc
  • Triacetin

0.5 mg / 0.1 mg tablet

Same active and inactive ingredients as Activella.

BrandActivella
Authorized genericAmneal Pharmaceuticals
See the ingredients

Active: estradiol 0.5 mg · norethindrone acetate 0.1 mg

Inactive, on both labels:

  • Hydroxypropyl cellulose
  • Hypromelloses
  • Lactose monohydrate
  • Magnesium stearate
  • Corn starch
  • Talc
  • Triacetin

Regular genericWho makes it

4 companies sell a generic of Activella that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

  • Breckenridge PharmaceuticalAll 2 strengths

    Has lactose

    How it looks, what’s in it, NDCs

    0.5 mg / 0.1 mg White, round, 6 mm, marked “B / 623”

    PackageNDC
    Carton of 2851991-623-28

    1 mg / 0.5 mg White, round, 6 mm, marked “B / 474”

    PackageNDC
    Carton of 2851991-474-28

    Inactive ingredients: lactose monohydrate, starch, corn, copovidone k25-31, talc, magnesium stearate, hypromellose, triacetin

    FDA label

  • Ingenus PharmaceuticalsAll 2 strengths

    Has lactose · Has dyes: D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, FD&C Red No. 40 · Made by Novast Laboratories

    How it looks, what’s in it, NDCs

    0.5 mg / 0.1 mg Pale yellow, round, 5 mm, marked “J1”

    PackageNDC
    Carton of 2850742-658-28
    Carton of 8450742-658-84
    Carton of 16850742-658-68

    1 mg / 0.5 mg Yellow, round, 5 mm, marked “J2”

    PackageNDC
    Carton of 2850742-657-28
    Carton of 8450742-657-84
    Carton of 16850742-657-68

    Inactive ingredients: lactose monohydrate, starch, corn, polysorbate 80, copovidone k25-31, magnesium stearate, polyvinyl alcohol, titanium dioxide, talc, polyethylene glycol 3350, lecithin, soybean, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Yellow No. 6, FD&C Red No. 40

    FDA label

  • Teva Pharmaceuticals1 mg / 0.5 mg

    Has lactose · Sold as Mimvey · Made by Barr

    How it looks, what’s in it, NDCs

    1 mg / 0.5 mg White, round, 6 mm, marked “b / 34”

    PackageNDC
    Carton of 280093-5455-28
    Carton of 1400093-5455-42

    Inactive ingredients: silicon dioxide, copovidone k25-31, starch, corn, hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), lactose monohydrate, magnesium stearate, polyethylene glycol 400, polysorbate 80, titanium dioxide

    FDA label

  • XiromedAll 2 strengths

    Has lactose · Has a dye: FD&C Yellow No. 6 · Sold as Abigale or Abigale LO

    Product page on xiromed.com

    How it looks, what’s in it, NDCs

    0.5 mg / 0.1 mg Light, round, 6 mm, marked “55”

    PackageNDC
    Carton of 8470700-303-85

    1 mg / 0.5 mg Orange, round, 6 mm, marked “263”

    PackageNDC
    Carton of 8470700-330-85

    Inactive ingredients: copovidone k25-31, FD&C Yellow No. 6, lactose monohydrate, magnesium stearate, starch, corn, talc

    FDA label

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

Activella is an estrogen and progestin combination indicated in a woman with a uterus for:

  • Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause
  • Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause Limitations of Use: When prescribing solely for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause, first consider the use of topical vaginal products.
  • Prevention of Postmenopausal Osteoporosis

Limitations of Use:

When prescribing solely for the prevention of postmenopausal osteoporosis, first consider the use of non-estrogen medications. Consider estrogen therapy only for women at significant risk of osteoporosis.

Source: the FDA label for Activella (Amneal Pharmaceuticals LLC), November 30, 2023. Full label on DailyMed 

Good to know

Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/activella/