Brand-name prescription

Aklief

trifarotene

Compare your options

Compare	AkliefBrand name	Authorized genericWithout the Aklief name	Regular generictrifarotene
What pharmacies pay	$736per 45 g bottle	Not sold	Not sold
Same as Aklief?	The original	–	–
Ways to save	Maker’s cardas little as $20 for 45 gwith commercial insurance	–	–
With insurance	Your plan’s brand co-pay	–	–

No authorized generic: There isn’t one.

No regular generic: No generic is sold yet.

Prices are the average U.S. drugstores pay (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

The maker’s savings card

Rx Maker’s savings card Galderma

Galderma CAREConnect Patient Savings Card

With commercial insurance

as little as $20 for 45 g

Paying cash, no insurance

as little as $90 for 45 g

Get it on galdermacc.com

In the maker’s words

“Eligible patients may pay as little as: NOT COVERED/ PRODUCT SIZE COVERED CASH AKLIEF® 45 g $20 $90 (trifarotene) Cream, 0.005%…”

From the maker’s offer on galdermacc.com, checked September 25, 2026. What you pay depends on your plan. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Before you use a discount card

Discount cards like GoodRx take money off the pharmacy’s cash price. For a brand-name drug, that price is often still high. With commercial insurance, Aklief’s own card may bring it to as little as $20 for 45 g. Paying cash, the maker’s own price is as little as $90 for 45 g.

Look up the discount-card price, then compare it with this estimate. You can use a maker’s card or a discount card, but usually not both on the same fill.

What pharmacies pay

The average U.S. drugstores pay for each strength (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Strength	Aklief
0.005% creamper 45 g bottle	$736

Good to know

There’s no authorized generic of Aklief.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.