Amitiza vs. its authorized generic and generics

Strength How many

How to pay the least

From

$16.11 for 30 capsules delivered ($10.86 plus $5.25 shipping)

Generic lubiprostone from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic lubiprostone. It comes by mail.

Need it today? From $21.80 for 30 capsules with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.

See the price and get the card

A regular generic has the same active ingredient as Amitiza, and the FDA requires it to work the same way.

Compare every option

Brand nameAmitiza

Authorized genericlubiprostone

Regular genericlubiprostone

What you’d pay

At least$190for 30 capsules; pharmacies pay this

Cash priceAsk the pharmacyUsually among the lowest

From$16.11for 30 capsules at Cost Plus Drugs, with shipping

Same as Amitiza?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Amitiza’s maker. Ask the pharmacy for Amitiza’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Amitiza, without the brand name. Give the pharmacy its NDC to get it.

lubiprostone

Sold by (either works)

SpecGxThe company behind Amitiza
Dr. Reddy's Laboratories
Natco Pharma
Par Health
Sun Pharmaceutical Industries

Your strength

NDC to ask for

8 mcgcapsuleDr. Reddy's Laboratories
- 43598-163-6011-digit: 43598-0163-6060 capsules per bottle
8 mcgcapsuleNatco Pharma
- 69339-162-1711-digit: 69339-0162-1740 capsules
8 mcgcapsulePar Health
- 0254-3028-0211-digit: 00254-3028-0260 capsules per bottle
8 mcgcapsuleSpecGx
- 0406-6408-6011-digit: 00406-6408-6060 capsules per bottle
8 mcgcapsuleSun Pharmaceutical Industries
- 63304-351-6011-digit: 63304-0351-6060 capsules per bottle
24 mcgcapsuleDr. Reddy's Laboratories
- 43598-168-6011-digit: 43598-0168-6060 capsules per bottle
24 mcgcapsuleNatco Pharma
- 69339-163-1711-digit: 69339-0163-1740 capsules
24 mcgcapsulePar Health
- 0254-3029-0211-digit: 00254-3029-0260 capsules per bottle
24 mcgcapsuleSpecGx
- 0406-6424-6011-digit: 00406-6424-6060 capsules per bottle
24 mcgcapsuleSun Pharmaceutical Industries
- 63304-352-6011-digit: 63304-0352-6060 capsules per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Amitiza, can you tell me what I’d pay for the brand, for the authorized generic, and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

8 mcg capsule · Dr. Reddy's Laboratories

Same active and inactive ingredients as Amitiza.

Authorized generic package label from Dr. Reddy's Laboratories — Authorized genericDr. Reddy's Laboratories

See the ingredients

Active: lubiprostone 8 mcg

Inactive, on both labels:

Ferric oxide red
Gelatin
Medium-chain triglycerides
Sorbitol
Titanium dioxide
Water

24 mcg capsule · Dr. Reddy's Laboratories

Same active and inactive ingredients as Amitiza.

See the ingredients

Active: lubiprostone 24 mcg

Inactive, on both labels:

D&C Yellow No. 10
FD&C Red No. 40
Gelatin
Medium-chain triglycerides
Sorbitol
Water

8 mcg capsule · Natco Pharma

Same active and inactive ingredients as Amitiza.

Authorized generic package label from Natco Pharma — Authorized genericNatco Pharma

See the ingredients

Active: lubiprostone 8 mcg

Inactive, on both labels:

Ferric oxide red
Gelatin
Medium-chain triglycerides
Sorbitol
Titanium dioxide
Water

24 mcg capsule · Natco Pharma

Same active and inactive ingredients as Amitiza.

See the ingredients

Active: lubiprostone 24 mcg

Inactive, on both labels:

D&C Yellow No. 10
FD&C Red No. 40
Gelatin
Medium-chain triglycerides
Sorbitol
Water

8 mcg capsule · Par Health

Same active and inactive ingredients as Amitiza.

Authorized generic package label from Par Health — Authorized genericPar Health

See the ingredients

Active: lubiprostone 8 mcg

Inactive, on both labels:

Ferric oxide red
Gelatin
Medium-chain triglycerides
Sorbitol
Titanium dioxide
Water

24 mcg capsule · Par Health

Same active and inactive ingredients as Amitiza.

See the ingredients

Active: lubiprostone 24 mcg

Inactive, on both labels:

D&C Yellow No. 10
FD&C Red No. 40
Gelatin
Medium-chain triglycerides
Sorbitol
Water

8 mcg capsule · SpecGx

Same active and inactive ingredients as Amitiza.

Authorized generic package label from SpecGx — Authorized genericSpecGx

See the ingredients

Active: lubiprostone 8 mcg

Inactive, on both labels:

Ferric oxide red
Gelatin
Medium-chain triglycerides
Sorbitol
Titanium dioxide
Water

24 mcg capsule · SpecGx

Same active and inactive ingredients as Amitiza.

See the ingredients

Active: lubiprostone 24 mcg

Inactive, on both labels:

D&C Yellow No. 10
FD&C Red No. 40
Gelatin
Medium-chain triglycerides
Sorbitol
Water

8 mcg capsule · Sun Pharmaceutical Industries

Same active and inactive ingredients as Amitiza.

Authorized generic package label from Sun Pharmaceutical Industries — Authorized genericSun Pharmaceutical Industries

See the ingredients

Active: lubiprostone 8 mcg

Inactive, on both labels:

Ferric oxide red
Gelatin
Medium-chain triglycerides
Sorbitol
Titanium dioxide
Water

24 mcg capsule · Sun Pharmaceutical Industries

Same active and inactive ingredients as Amitiza.

See the ingredients

Active: lubiprostone 24 mcg

Inactive, on both labels:

D&C Yellow No. 10
FD&C Red No. 40
Gelatin
Medium-chain triglycerides
Sorbitol
Water

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic lubiprostone, lowest first.

Pick up in storeDelivered

Delivered: Cost Plus Drugs from $10.86for 30 capsules8 mcg $12.73 · 24 mcg $10.86Plus $5.25 shipping
Pick up in store: CVS Pharmacy + Optum Perks $36for 60 capsules24 mcgFree Optum Perks coupon · not with insuranceFind the nearest store
Delivered: Rx Outreach $41for 60 capsules8 mcg, 24 mcgFree delivery
Delivered: Amazon Pharmacy from $21.59for 30 capsules8 mcg $21.59 · 24 mcg $21.77Prime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
Pick up in store: Team Cuban Card from $21.80for 30 capsules8 mcg $21.80 · 24 mcg $22.43Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
Pick up in store: Costco $89.99for 60 capsules8 mcgMembers only · $65 a yearFind the nearest store
Delivered: Costco $89.99for 60 capsules8 mcgMembers only · $65 a year · Plus shipping
Pick up in store: Walgreens + Optum Perks $98.70for 60 capsules24 mcgFree Optum Perks coupon · not with insuranceFind the nearest store
Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

4 companies sell a generic of Amitiza that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Camber PharmaceuticalsAll 2 strengths

Has a dye: FD&C Yellow No. 6 · Made by Ascent Pharmaceuticals

Product page on camberpharma.com

How it looks, what’s in it, NDCs

0.008 mg Light orange, oval, 9 mm, marked “8”

Package NDC
Bottle of 60 31722-403-60

0.024 mg Clear orange, oval, 9 mm, marked “24”

Package NDC
Bottle of 60 31722-404-60

Inactive ingredients: gelatin, sorbitol solution, FD&C Yellow No. 6, titanium dioxide, medium-chain triglycerides, water, lecithin, soybean, ferrosoferric oxide, propylene glycol, hypromellose 2910 (6 mpa.s)
FDA label
NorthStar RxAll 2 strengths

Has a dye: FD&C Yellow No. 6 · Made by Ascent Pharmaceuticals

Product page on northstarrxllc.com

How it looks, what’s in it, NDCs

0.008 mg Light orange, oval, 9 mm, marked “8”

Package NDC
Bottle of 60 72603-288-01

0.024 mg Clear orange, oval, 9 mm, marked “24”

Package NDC
Bottle of 60 72603-289-01

Inactive ingredients: gelatin, sorbitol solution, FD&C Yellow No. 6, titanium dioxide, medium-chain triglycerides, water, lecithin, soybean, ferrosoferric oxide, propylene glycol, hypromellose 2910 (6 mpa.s)
FDA label
Teva PharmaceuticalsAll 2 strengths

Has dyes: D&C Yellow No. 10, FD&C Red No. 40

How it looks, what’s in it, NDCs

8 mcg Opaque pink, oval, 9 mm, marked “A08”

Package NDC
Bottle of 60 0480-3479-06

24 mcg Clear orange, oval, 9 mm, marked “A04”

Package NDC
Bottle of 60 0480-4138-06

Inactive ingredients: ferrosoferric oxide, ferric oxide red, gelatin, hypromellose, lecithin, soybean, medium-chain triglycerides, propylene glycol, water, sorbitol solution, titanium dioxide, D&C Yellow No. 10, FD&C Red No. 40
FDA label
Zydus LifesciencesAll 2 strengths

How it looks, what’s in it, NDCs

8 mcg Light pink to pink colored, oval, 9 mm, marked “8”

Package NDC
Bottle of 60 70710-1641-6
Bottle of 100 70710-1641-1

24 mcg Light yellow colored, oval, 9 mm, marked “24”

Package NDC
Bottle of 60 70710-1642-6
Bottle of 100 70710-1642-1

Inactive ingredients: 1,4-sorbitan, ferric oxide red, ferrosoferric oxide, gelatin, medium-chain triglycerides, propylene glycol, shellac, sorbitol, titanium dioxide, water
FDA label

Package	NDC
Bottle of 60	31722-403-60

Package	NDC
Bottle of 60	31722-404-60

Package	NDC
Bottle of 60	72603-288-01

Package	NDC
Bottle of 60	72603-289-01

Package	NDC
Bottle of 60	0480-3479-06

Package	NDC
Bottle of 60	0480-4138-06

Package	NDC
Bottle of 60	70710-1641-6
Bottle of 100	70710-1641-1

Package	NDC
Bottle of 60	70710-1642-6
Bottle of 100	70710-1642-1

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

Amitiza is a chloride channel activator indicated for the treatment of:

chronic idiopathic constipation (CIC) in adults.
opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation.
- Limitations of Use: Effectiveness of Amitiza in the treatment of OIC in patients taking diphenylheptane opioids (e.g., methadone) has not been established.
irritable bowel syndrome with constipation (IBS-C) in women ≥ 18 years old.

Source: the FDA label for Amitiza (SpecGx LLC), July 10, 2026. Full label on DailyMed

Good to know

It may look different from Amitiza (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/amitiza/