Arthrotec vs. its authorized generic and generics

Strength How many

How to pay the least

From

$22.08 for 30 tablets delivered ($16.83 plus $5.25 shipping)

Generic diclofenac and misoprostol from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic diclofenac and misoprostol. It comes by mail.

Need it today? From $25.72 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.

See the price and get the card

A regular generic has the same active ingredient as Arthrotec, and the FDA requires it to work the same way.

Compare every option

Brand nameArthrotec

Authorized genericdiclofenac and misoprostol

Regular genericdiclofenac and misoprostol

What you’d pay

At least$250for 30 tablets; pharmacies pay this

Cash priceAsk the pharmacyUsually among the lowest

From$22.08for 30 tablets at Cost Plus Drugs, with shipping

Same as Arthrotec?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Arthrotec’s maker. Ask the pharmacy for Arthrotec’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Arthrotec, without the brand name. Give the pharmacy its NDC to get it.

diclofenac and misoprostol

Sold by

Mylan Pharmaceuticals

Your strength

NDC to ask for

50 mg / 200 mcgtablet
- 59762-0028-111-digit: 59762-0028-0160 tablets per bottle
- 59762-0028-211-digit: 59762-0028-0290 tablets per bottle
75 mg / 200 mcgtablet
- 59762-0029-111-digit: 59762-0029-0160 tablets per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Arthrotec, can you tell me what I’d pay for the brand, for the authorized generic from Mylan Pharmaceuticals, and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

50 mg / 200 mcg tablet

Same active ingredient. A few inactive ingredients are listed differently (below). Ask your pharmacist if that matters for you, for example with an allergy.

Arthrotec package label — BrandArthrotec

Authorized generic package label from Mylan Pharmaceuticals — Authorized genericMylan Pharmaceuticals

See the ingredients

Active: diclofenac sodium 50 mg · misoprostol 200 mcg

Inactive, on both labels:

Crospovidone
Hydrogenated castor oil
Hypromellose
Lactose
Magnesium stearate
Microcrystalline cellulose
Povidone k30
Silicon dioxide
Sodium hydroxide
Corn starch
Talc
Triethyl citrate

Only on Arthrotec’s label: Methacrylic acid - methyl methacrylate copolymer

75 mg / 200 mcg tablet

Same active ingredient. A few inactive ingredients are listed differently (below). Ask your pharmacist if that matters for you, for example with an allergy.

See the ingredients

Active: diclofenac sodium 75 mg · misoprostol 200 mcg

Inactive, on both labels:

Crospovidone
Hydrogenated castor oil
Hypromellose
Lactose
Magnesium stearate
Microcrystalline cellulose
Povidone k30
Silicon dioxide
Sodium hydroxide
Corn starch
Talc
Triethyl citrate

Only on Arthrotec’s label: Methacrylic acid - methyl methacrylate copolymer

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic diclofenac and misoprostol, lowest first.

Pick up in storeDelivered

Delivered: Cost Plus Drugs from $16.83for 30 tablets50 mg / 200 mcg $16.83 · 75 mg / 200 mcg $20.77Plus $5.25 shipping
Pick up in store: Walgreens + Optum Perks $49.13for 60 tablets75 mg / 200 mcgFree Optum Perks coupon · not with insuranceFind the nearest store
Pick up in store: CVS Pharmacy + Optum Perks $50.54for 60 tablets75 mg / 200 mcgFree Optum Perks coupon · not with insuranceFind the nearest store
Delivered: Amazon Pharmacy from $25.40for 30 tablets50 mg / 200 mcg $25.40 · 75 mg / 200 mcg $45.50Prime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
Pick up in store: Team Cuban Card from $25.72for 30 tablets50 mg / 200 mcg $25.72 · 75 mg / 200 mcg $27.14Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
Pick up in store: Costco $74.79for 60 tablets75 mg / 200 mcgMembers only · $65 a yearFind the nearest store
Delivered: Costco $74.79for 60 tablets75 mg / 200 mcgMembers only · $65 a year · Plus shipping
Delivered: Rx Outreach $45for 30 tablets50 mg / 200 mcg, 75 mg / 200 mcgeach additional 30 tablets: $10Free delivery
Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

5 companies sell a generic of Arthrotec that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Actavis PharmaDR tablet 50 mg / 200 mcg, 75 mg / 200 mcg

Has lactose

How it looks, what’s in it, NDCs

50 mg / 200 mcg White to off-white, round, 11 mm, marked “0397”

Package NDC
Bottle of 60 0591-0397-60
Bottle of 90 0591-0397-19

75 mg / 200 mcg White to off-white, round, 11 mm, marked “0398”

Package NDC
Bottle of 60 0591-0398-60

Inactive ingredients: silicon dioxide, crospovidone, hydrogenated castor oil, hypromelloses, lactose monohydrate, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, cellulose, microcrystalline, povidone k30, sodium hydroxide, starch, corn, talc, triethyl citrate
Amneal PharmaceuticalsDR tablet 50 mg / 200 mcg, 75 mg / 200 mcg

Has lactose

How it looks, what’s in it, NDCs

50 mg / 200 mcg White, round, 11 mm, marked “AN / 436”

Package NDC
Bottle of 30 65162-436-03
Bottle of 60 65162-436-06
Bottle of 90 65162-436-09
Bottle of 100 65162-436-10

75 mg / 200 mcg White, round, 11 mm, marked “AN / 438”

Package NDC
Bottle of 30 65162-438-03
Bottle of 60 65162-438-06
Bottle of 100 65162-438-10

Inactive ingredients: silicon dioxide, starch, corn, crospovidone (12 mpa.s at 5%), hydrogenated castor oil, hypromelloses, lactose monohydrate, magnesium stearate, methacrylic acid - ethyl acrylate copolymer (1:2), cellulose, microcrystalline, povidone, sodium hydroxide, talc, triethyl citrate
FDA label
BluePoint LaboratoriesDR tablet 50 mg / 200 mcg, 75 mg / 200 mcg

Has lactose · Made by Actavis Laboratories FL

How it looks, what’s in it, NDCs

50 mg / 200 mcg White to off-white, round, 11 mm, marked “0397”

Package NDC
Bottle of 60 68001-231-06

75 mg / 200 mcg White to off-white, round, 11 mm, marked “0398”

Package NDC
Bottle of 60 68001-232-06

Inactive ingredients: silicon dioxide, crospovidone, hydrogenated castor oil, hypromelloses, lactose monohydrate, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, cellulose, microcrystalline, povidone k30, sodium hydroxide, starch, corn, talc, triethyl citrate
FDA label
Micro LabsTablet 50 mg / 200 mcg, 75 mg / 200 mcg

Has lactose

Product page on microlabsusa.com

How it looks, what’s in it, NDCs

50 mg / 200 mcg White to off-white, round, 11 mm, marked “D50M”

Package NDC
Bottle of 30 42571-133-30
Bottle of 60 42571-133-60
Bottle of 90 42571-133-90
Carton of 600 42571-133-29

75 mg / 200 mcg White to off-white, round, 11 mm, marked “D75M”

Package NDC
Bottle of 30 42571-134-30
Bottle of 60 42571-134-60
Bottle of 90 42571-134-90
Carton of 600 42571-134-29

Inactive ingredients: silicon dioxide, starch, corn, crospovidone, hydrogenated castor oil, hypromelloses, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium hydroxide, talc, triethyl citrate, methacrylic acid and ethyl acrylate copolymer
FDA label
Nivagen PharmaceuticalsDR tablet 50 mg / 200 mcg, 75 mg / 200 mcg

Has lactose · Made by Yung Shin Pharmaceutical Industrial

How it looks, what’s in it, NDCs

50 mg / 200 mcg White, round, 13 mm, marked “YSP / 167”

Package NDC
Bottle of 60 75834-264-60
Bottle of 90 75834-264-90

75 mg / 200 mcg White, round, 13 mm, marked “YSP / 168”

Package NDC
Bottle of 60 75834-265-60

Inactive ingredients: silicon dioxide, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, cellulose, microcrystalline, polyethylene glycol, povidone k30, starch, corn, titanium dioxide, triethyl citrate, carnauba wax
FDA label

Package	NDC
Bottle of 60	0591-0397-60
Bottle of 90	0591-0397-19

Package	NDC
Bottle of 60	0591-0398-60

Package	NDC
Bottle of 30	65162-436-03
Bottle of 60	65162-436-06
Bottle of 90	65162-436-09
Bottle of 100	65162-436-10

Package	NDC
Bottle of 30	65162-438-03
Bottle of 60	65162-438-06
Bottle of 100	65162-438-10

Package	NDC
Bottle of 60	68001-231-06

Package	NDC
Bottle of 60	68001-232-06

Package	NDC
Bottle of 30	42571-133-30
Bottle of 60	42571-133-60
Bottle of 90	42571-133-90
Carton of 600	42571-133-29

Package	NDC
Bottle of 30	42571-134-30
Bottle of 60	42571-134-60
Bottle of 90	42571-134-90
Carton of 600	42571-134-29

Package	NDC
Bottle of 60	75834-264-60
Bottle of 90	75834-264-90

Package	NDC
Bottle of 60	75834-265-60

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

ARTHROTEC is a combination of diclofenac sodium, a non-steroidal anti-inflammatory drug, and misoprostol, a prostaglandin-1 (PGE1) analog, indicated for the treatment of signs and symptoms of osteoarthritis or rheumatoid arthritis in adult patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications.

Source: the FDA label for Arthrotec (Pfizer Laboratories Div Pfizer Inc), August 14, 2025. Full label on DailyMed

Good to know

It may look different from Arthrotec (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/arthrotec/