Daraprim vs. its authorized generic and generics

How to pay the least

Lowest price

$1,099.31 for 30 tablets delivered ($1,094.06 plus $5.25 shipping)

Generic pyrimethamine 25 mg from Cost Plus Drugs, by mail

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic pyrimethamine 25 mg. It comes by mail.

A regular generic has the same active ingredient as Daraprim, and the FDA requires it to work the same way.

Compare every option

Brand nameDaraprim

Authorized genericpyrimethamine

Regular genericpyrimethamine

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Cash priceAsk the pharmacyOften less than Daraprim

Lowest$1,099.31for 30 tablets at Cost Plus Drugs, with shipping

Same as Daraprim?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

Daraprim’s maker has a savings card that lowers what you pay at the pharmacy.

DARAPRIM Direct copay program

Savings card from Tilde Sciences

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $0 a prescription

The card takes up to $13,500 a fill off your co-pay.

Or call 1-877-258-2033.

In the maker’s words

“If you have commercial or private insurance, you may pay as little as $0 out-of-pocket for your prescription…”

From the maker’s offer on daraprimdirect.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericThe NDC to ask for

The same medicine as Daraprim, without the brand name. Give the pharmacy its NDC to get it.

pyrimethamine

Sold by

Oakrum Pharma

How to get it

The maker sells this through a specialty pharmacy and lists an enrollment form for its Toxo Total Care program. Ask your doctor to confirm how to order it, since program details may have changed.

Maker’s product page

NDC to ask for

25 mgtablet
- 72647-330-0111-digit: 72647-0330-01100 tablets per bottle
- 72647-330-0311-digit: 72647-0330-0330 tablets per bottle

Source: FDA, updated October 30, 2026

What to ask your doctor

“Can you check how to order pyrimethamine, the authorized generic of Daraprim, through its specialty pharmacy? The NDC is 72647-330-01.”

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Same active and inactive ingredients as Daraprim.

See the ingredients

Active: pyrimethamine 25 mg

Inactive, on both labels:

Lactose
Magnesium stearate
Corn starch
Potato starch

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic pyrimethamine, lowest first.

Delivered

Delivered: Cost Plus Drugs $1,094.06for 30 tablets25 mgPlus $5.25 shipping
Delivered: Amazon Pharmacy $6,143for 21 tablets25 mgPrime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericMakers and their savings programs

3 companies sell a generic of Daraprim that the FDA rates a substitute. A pharmacy fills whichever one it stocks. One of them has its own savings program, listed first. It works only with that maker’s version. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Dr. Reddy’s Laboratories25 mg

Has lactose · Made by Pharmazone

Dr. Reddy's pyrimethamine co-pay card

“Pyrimethamine Tablets USP, 25 mg Co-pay Card”

Get the card

How it looks, what’s in it, NDCs

25 mg White, round, 7 mm, marked “C127”

Package NDC
Bottle of 30 43598-672-30
Bottle of 100 43598-672-01

Inactive ingredients: starch, corn, lactose monohydrate, magnesium stearate
FDA label
Aurobindo Pharma25 mg

Has lactose

Product page on aurobindousa.com

How it looks, what’s in it, NDCs

25 mg White to off-white, round, 7 mm, marked “L / 25”

Package NDC
Bottle of 30 59651-590-30
Bottle of 100 59651-590-01

Inactive ingredients: silicon dioxide, lactose monohydrate, magnesium stearate, starch, corn
FDA label
Teva Pharmaceuticals25 mg

How it looks, what’s in it, NDCs

25 mg White, round, 8 mm, marked “2P / T”

Package NDC
Bottle of 30 0480-3720-56
Bottle of 100 0480-3720-01

Inactive ingredients: starch, corn, magnesium stearate, mannitol
FDA label

Package	NDC
Bottle of 30	43598-672-30
Bottle of 100	43598-672-01

Package	NDC
Bottle of 30	59651-590-30
Bottle of 100	59651-590-01

Package	NDC
Bottle of 30	0480-3720-56
Bottle of 100	0480-3720-01

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

Toxoplasmosis (a parasite infection)

What the FDA label says

Treatment of Toxoplasmosis: DARAPRIM is indicated for the treatment of toxoplasmosis when used conjointly with a sulfonamide, since synergism exists with this combination.

Source: the FDA label for Daraprim (TILDE Sciences LLC), December 7, 2023. Full label on DailyMed

Good to know

It may look different from Daraprim (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/daraprim/