Depakote ER vs. its authorized generic and generics

Strength How many

How to pay the least

From

$11.78 for 30 tablets delivered ($6.53 plus $5.25 shipping)

Generic divalproex ER from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic divalproex ER. It comes by mail.

Need it today? From $14.98 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.

See the price and get the card

A regular generic has the same active ingredient as Depakote ER, and the FDA requires it to work the same way.

Compare every option

Brand nameDepakote ER

Authorized genericdivalproex

Regular genericdivalproex

What you’d pay

At least$110for 30 tablets; pharmacies pay this

Not soldNo longer sold

From$11.78for 30 tablets at Cost Plus Drugs, with shipping

Same as Depakote ER?

The original

–

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

Depakote ER’s maker has a savings card that lowers what you pay at the pharmacy.

Depakote Savings Card

Savings card from AbbVie

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $5 a month

The card takes up to $150 a month off your co-pay.

Or call 1-833-440-2659.

In the maker’s words

“With a Depakote Savings Card, eligible patients may pay as little as $5 a month—that's as little as 17¢ per day.”

From the maker’s offer on depakote.com, checked October 27, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericNot sold now

An authorized generic of Depakote ER was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (divalproex sodium) is available.

Source: FDA, updated October 30, 2026

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic divalproex, lowest first.

Pick up in storeDelivered

Delivered: Marley Drug $37for a 6-month supplyNot every strength is on its list12-month supply: $70Shipping included
Delivered: Cost Plus Drugs from $6.53for 30 tablets250 mg $6.53 · 500 mg $7.35Plus $5.25 shipping
Pick up in store: Costco $20.99for 60 tablets500 mgMembers only · $65 a yearFind the nearest store
Delivered: Costco $20.99for 60 tablets500 mgMembers only · $65 a year · Plus shipping
Delivered: Optum Perks $25.91for 60 tablets500 mgPlus $5 shipping · Not with insurance
Pick up in store: Target (CVS) + Optum Perks $27.99for 60 tablets500 mgFree Optum Perks coupon · not with insuranceFind the nearest store
Pick up in store: CVS Pharmacy + Optum Perks $28.26for 60 tablets500 mgFree Optum Perks coupon · not with insuranceFind the nearest store
Pick up in store: Team Cuban Card from $14.98for 30 tablets250 mg $14.98 · 500 mg $16.22Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
Pick up in store: Walgreens + Optum Perks $57.83for 60 tablets500 mgFree Optum Perks coupon · not with insuranceFind the nearest store
Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

10 companies sell a generic of Depakote ER that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Amneal PharmaceuticalsAll 2 strengths

Has lactose

How it looks, what’s in it, NDCs

250 mg White to off-white, round, 11 mm, marked “AN / 755”

Package NDC
Bottle of 100 65162-755-10
Bottle of 500 65162-755-50

500 mg White to off-white, capsule, 21 mm, marked “AN / 757”

Package NDC
Bottle of 100 65162-757-10
Bottle of 500 65162-757-50

Inactive ingredients: ammonia, ethyl acrylate, methacrylic acid - methyl methacrylate copolymer (1:1), hypromelloses, ferrosoferric oxide, isopropyl alcohol, lactose monohydrate, polyethylene glycol, magnesium stearate, cellulose, microcrystalline, butyl alcohol, polyvinyl alcohol, propylene glycol, shellac, silicon dioxide, talc, titanium dioxide
FDA label
Aurobindo PharmaAll 2 strengths

Has dyes: FD&C Blue No. 1, FD&C Blue No. 2

Product page on aurobindousa.com

How it looks, what’s in it, NDCs

250 mg White to Off-white, oval, 16 mm, marked “I49”

Package NDC
Bottle of 60 65862-594-60
Bottle of 100 65862-594-01
Carton of 100 65862-594-10
Bottle of 500 65862-594-05
Bottle of 1000 65862-594-99

500 mg Gray, oval, 19 mm, marked “I50”

Package NDC
Bottle of 100 65862-595-01
Carton of 100 65862-595-10
Bottle of 500 65862-595-05

Inactive ingredients: FD&C Blue No. 1, FD&C Blue No. 2, hypromellose 2208 (100 mpa.s), hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), mannitol, methacrylic acid - ethyl acrylate copolymer (1:1) type a, polyethylene glycol 8000, starch, corn, propylene glycol, shellac, microcrystalline cellulose, silicon dioxide, titanium dioxide, triacetin, ferrosoferric oxide, ferric oxide yellow, polydextrose
BluePoint LaboratoriesAll 2 strengths

Has lactose · Made by Unichem Pharmaceuticals and Zydus Lifesciences

How it looks, what’s in it, NDCs

250 mg WHITE TO OFF-WHITE, capsule, 18 mm, marked “ZA47”

Package NDC
Bottle of 100 68001-105-00
Bottle of 500 68001-105-03

250 mg Pink, oval, 16 mm, marked “U / 380”

Package NDC
Bottle of 100 68001-646-00
Bottle of 500 68001-646-03

500 mg WHITE TO OFF-WHITE, capsule, 23 mm, marked “ZA48”

Package NDC
Bottle of 100 68001-106-00
Bottle of 500 68001-106-03

500 mg Yellow, oval, 19 mm, marked “U / 381”

Package NDC
Bottle of 100 68001-647-00
Bottle of 500 68001-647-03

Inactive ingredients: hydroxypropyl cellulose (1600000 wamw), hypromellose, lecithin, soybean, magnesium stearate, polyethylene glycol, polyvinyl alcohol, silicon dioxide, talc, titanium dioxide, xanthan gum, ethylcellulose (10 mpa.s), ferric oxide red, ferrosoferric oxide, hypromellose 2208 (15000 mpa.s), hypromellose 2910 (15 mpa.s), lactose monohydrate, propyl gallate, propylene glycol, shellac, stearic acid, triacetin, ferric oxide yellow
FDA label
Camber PharmaceuticalsAll 2 strengths

Made by Annora Pharma

Product page on camberpharma.com

How it looks, what’s in it, NDCs

250 mg White to off white, oval, 16 mm, marked “V23”

Package NDC
Bottle of 100 31722-021-01
Bottle of 500 31722-021-05

500 mg White to off white, oval, 19 mm, marked “V24”

Package NDC
Bottle of 100 31722-022-01
Bottle of 500 31722-022-05

Inactive ingredients: hypromellose 2208 (15000 mpa.s), microcrystalline cellulose 101, silicon dioxide, lecithin, soybean, polyvinyl alcohol, talc, titanium dioxide, xanthan gum, ammonia, ferrosoferric oxide, propylene glycol, shellac, hypromellose 2208 (4000 mpa.s), microcrystalline cellulose 102
FDA label
Dr. Reddy’s LaboratoriesAll 2 strengths

Has lactose · Made by Doctor Reddys Laboratories

How it looks, what’s in it, NDCs

250 mg White to off white, round, 11 mm, marked “R / 533”

Package NDC
Bottle of 30 55111-533-30
Bottle of 60 55111-533-60
Bottle of 100 55111-533-01
Carton of 100 55111-533-78
Bottle of 500 55111-533-05

500 mg Gray, oval, 20 mm, marked “R / 534”

Package NDC
Bottle of 30 55111-534-30
Bottle of 60 55111-534-60
Bottle of 100 55111-534-01
Bottle of 500 55111-534-05

Inactive ingredients: hypromelloses, hydroxyethyl cellulose (2000 cps at 1%), lactose monohydrate, cellulose, microcrystalline, silicon dioxide, titanium dioxide, polyethylene glycol 400, hypromellose 2208 (15000 mpa.s), hydroxypropyl cellulose (1600000 wamw), ferrosoferric oxide, ferric oxide yellow
FDA label
Lupin PharmaceuticalsAll 2 strengths

Has lactose

How it looks, what’s in it, NDCs

250 mg White, oval, 14 mm, marked “L088”

Package NDC
Bottle of 100 68180-260-01
Bottle of 500 68180-260-02

500 mg Gray, oval, 19 mm, marked “L089”

Package NDC
Bottle of 100 68180-261-01
Bottle of 500 68180-261-02

Inactive ingredients: cellulose, microcrystalline, ethyl acrylate and methyl methacrylate copolymer (2:1; 750000 mw), ethylcellulose (7 mpa.s), ferrosoferric oxide, hypromellose 2208 (100000 mpa.s), lactose monohydrate, magnesium stearate, polyethylene glycol 3350, polyethylene glycol 6000, polyvinyl alcohol, propylene glycol, shellac, silicon dioxide, talc, titanium dioxide, ferric oxide red, ferric oxide yellow
FDA label
Mylan InstitutionalAll 2 strengths

How it looks, what’s in it, NDCs

250 mg White, round, 12 mm, marked “M / 177”

Package NDC
Carton of 80 51079-766-08

500 mg White, oval, 21 mm, marked “M / 473”

Package NDC
Carton of 80 51079-767-08

Inactive ingredients: ammonia, silicon dioxide, dibutyl sebacate, ethylcellulose, hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), hypromellose 2910 (50 mpa.s), hydroxyethyl cellulose, oleic acid, polydextrose, polyethylene glycol 400, polyethylene glycol 8000, microcrystalline cellulose, titanium dioxide, triacetin
FDA label
Mylan PharmaceuticalsAll 2 strengths

Product page on viatris.com

How it looks, what’s in it, NDCs

250 mg White, round, 12 mm, marked “M / 177”

Package NDC
Bottle of 100 0378-0472-01
Bottle of 500 0378-0472-05

500 mg White, oval, 21 mm, marked “M / 473”

Package NDC
Bottle of 100 0378-0473-01
Bottle of 500 0378-0473-05

Inactive ingredients: ammonia, silicon dioxide, dibutyl sebacate, ethylcellulose, hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), hypromellose 2910 (50 mpa.s), hydroxyethyl cellulose, oleic acid, polydextrose, polyethylene glycol 400, polyethylene glycol 8000, microcrystalline cellulose, titanium dioxide, triacetin
NorthStar RxAll 2 strengths

Has dyes: FD&C Blue No. 1, FD&C Blue No. 2 · Made by Aurobindo Pharma

Product page on northstarrxllc.com

How it looks, what’s in it, NDCs

250 mg White to Off-white, oval, 16 mm, marked “I49”

Package NDC
Bottle of 100 16714-484-01
Bottle of 500 16714-484-02

500 mg Gray, oval, 19 mm, marked “I50”

Package NDC
Bottle of 100 16714-485-01
Bottle of 500 16714-485-02

Inactive ingredients: FD&C Blue No. 1, FD&C Blue No. 2, hypromellose 2208 (100 mpa.s), hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), mannitol, methacrylic acid - ethyl acrylate copolymer (1:1) type a, polyethylene glycol 8000, starch, corn, propylene glycol, shellac, microcrystalline cellulose, silicon dioxide, titanium dioxide, triacetin, ferrosoferric oxide, ferric oxide yellow, polydextrose
FDA label
Unichem PharmaceuticalsAll 2 strengths

Has lactose

Product page on unichemusa.com

How it looks, what’s in it, NDCs

250 mg Pink, oval, 16 mm, marked “U / 380”

Package NDC
Bottle of 100 29300-380-01
Bottle of 500 29300-380-05

500 mg Yellow, oval, 19 mm, marked “U / 381”

Package NDC
Bottle of 100 29300-381-01
Bottle of 500 29300-381-05

Inactive ingredients: ethylcellulose (10 mpa.s), ferric oxide red, ferrosoferric oxide, hypromellose 2208 (15000 mpa.s), hypromellose 2910 (15 mpa.s), lactose monohydrate, propyl gallate, propylene glycol, shellac, silicon dioxide, stearic acid, talc, titanium dioxide, triacetin, ferric oxide yellow
FDA label

Package	NDC
Bottle of 100	65162-755-10
Bottle of 500	65162-755-50

Package	NDC
Bottle of 100	65162-757-10
Bottle of 500	65162-757-50

Package	NDC
Bottle of 60	65862-594-60
Bottle of 100	65862-594-01
Carton of 100	65862-594-10
Bottle of 500	65862-594-05
Bottle of 1000	65862-594-99

Package	NDC
Bottle of 100	65862-595-01
Carton of 100	65862-595-10
Bottle of 500	65862-595-05

Package	NDC
Bottle of 100	68001-105-00
Bottle of 500	68001-105-03

Package	NDC
Bottle of 100	68001-646-00
Bottle of 500	68001-646-03

Package	NDC
Bottle of 100	68001-106-00
Bottle of 500	68001-106-03

Package	NDC
Bottle of 100	68001-647-00
Bottle of 500	68001-647-03

Package	NDC
Bottle of 100	31722-021-01
Bottle of 500	31722-021-05

Package	NDC
Bottle of 100	31722-022-01
Bottle of 500	31722-022-05

Package	NDC
Bottle of 30	55111-533-30
Bottle of 60	55111-533-60
Bottle of 100	55111-533-01
Carton of 100	55111-533-78
Bottle of 500	55111-533-05

Package	NDC
Bottle of 30	55111-534-30
Bottle of 60	55111-534-60
Bottle of 100	55111-534-01
Bottle of 500	55111-534-05

Package	NDC
Bottle of 100	68180-260-01
Bottle of 500	68180-260-02

Package	NDC
Bottle of 100	68180-261-01
Bottle of 500	68180-261-02

Package	NDC
Carton of 80	51079-766-08

Package	NDC
Carton of 80	51079-767-08

Package	NDC
Bottle of 100	0378-0472-01
Bottle of 500	0378-0472-05

Package	NDC
Bottle of 100	0378-0473-01
Bottle of 500	0378-0473-05

Package	NDC
Bottle of 100	16714-484-01
Bottle of 500	16714-484-02

Package	NDC
Bottle of 100	16714-485-01
Bottle of 500	16714-485-02

Package	NDC
Bottle of 100	29300-380-01
Bottle of 500	29300-380-05

Package	NDC
Bottle of 100	29300-381-01
Bottle of 500	29300-381-05

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

Depakote ER is indicated for:

Acute treatment of manic or mixed episodes associated with bipolar disorder, with or without psychotic features
Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures
Prophylaxis of migraine headaches

Source: the FDA label for Depakote ER (AbbVie Inc.), March 31, 2026. Full label on DailyMed

Prices checked October 27, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/depakote-er/