Doryx vs. its authorized generic and generics

How many

How to pay the least

Lowest price

$98.26 for 30 tablets delivered ($93.01 plus $5.25 shipping)

Generic doxycycline hyclate DR 200 mg from Cost Plus Drugs, by mail

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic doxycycline hyclate DR 200 mg. It comes by mail.

A regular generic has the same active ingredient as Doryx, and the FDA requires it to work the same way.

Compare every option

Brand nameDoryx

Authorized genericdoxycycline hyclate

Regular genericdoxycycline hyclate

What you’d pay

Not soldNo longer sold

Cash priceAsk the pharmacyUsually among the lowest

Cash price$98.26for 30 tablets at Cost Plus Drugs, with shipping

Same as Doryx?

–

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameNot sold

Doryx itself isn’t sold as a prescription anymore. Its generic versions, if any, are in the other tabs.

See the authorized generic →

Authorized genericThe NDC to ask for

The same medicine as Doryx, without the brand name. Give the pharmacy its NDC to get it.

doxycycline hyclate

Sold by

Mayne Pharma CommercialThe company behind Doryx

NDC to ask for

200 mgdelayed-release tablet
- 68308-716-3011-digit: 68308-0716-3030 tablets per bottle
- 68308-716-6011-digit: 68308-0716-6060 tablets per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Doryx, can you tell me what I’d pay for the brand, for the authorized generic from Mayne Pharma Commercial (NDC 68308-716-30), and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Doryx doesn’t come in this strength, so there’s no brand label to compare.

Authorized generic package label from Mayne Pharma Commercial — Authorized genericMayne Pharma Commercial

See the ingredients

Active: doxycycline hyclate 200 mg

Inactive:

Anhydrous lactose
Crospovidone
Hypromellose 2910
Hypromellose phthalate
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Sodium chloride
Sodium lauryl sulfate
Corn starch
Talc
Triethyl citrate

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic doxycycline hyclate, lowest first.

Delivered

Delivered: Cost Plus Drugs from $31.88for 30 tablets50 mg $57.06 · 100 mg $100.36 · 150 mg $31.88 · 200 mg $93.01Plus $5.25 shipping

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

4 companies sell a generic of Doryx that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Actavis Pharma50 mg, 200 mg

Has a dye: D&C Yellow No. 10 aluminum lake · Being phased out; sold until June 2027

How it looks, what’s in it, NDCs

50 mg Contains yellow to brown pellets, oval, 11 mm, marked “T / 0”

Package NDC
Bottle of 120 0591-4550-22

200 mg Contains yellow to brown pellets, oval, 19 mm, marked “T / 9”

Package NDC
Bottle of 60 0591-4575-60

Inactive ingredients: crospovidone, D&C Yellow No. 10 aluminum lake, hypromellose 2910 (5 mpa.s), hypromellose phthalate (24% phthalate, 55 cst), magnesium stearate, mannitol, microcrystalline cellulose, povidone, silicified microcrystalline cellulose (125 .micro.m), talc, triethyl citrate
FDA label
Alembic Pharmaceuticals75 mg, 100 mg, 150 mg, 200 mg

Has lactose

How it looks, what’s in it, NDCs

75 mg Containing yellow specks, oval, 13 mm, marked “L241”

Package NDC
Bottle of 60 62332-481-60
Bottle of 100 62332-481-31
Bottle of 1000 62332-481-91

100 mg Containing yellow specks, oval, 16 mm, marked “L242”

Package NDC
Bottle of 60 62332-482-60
Bottle of 100 62332-482-31
Bottle of 1000 62332-482-91

150 mg Containing yellow specks, rectangle, 18 mm, marked “2 / 4 / 3 / L”

Package NDC
Bottle of 30 62332-483-30
Bottle of 60 62332-483-60
Bottle of 100 62332-483-31
Bottle of 500 62332-483-71

200 mg Containing yellow specks, oval, 19 mm, marked “L594”

Package NDC
Bottle of 30 62332-484-30
Bottle of 60 62332-484-60
Bottle of 100 62332-484-31
Bottle of 500 62332-484-71

Inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, sodium chloride, povidone k30, hypromellose, talc, triethyl citrate, polyethylene glycol 6000, hydroxypropyl cellulose, low substituted, crospovidone, silicon dioxide, starch, corn, hypromellose phthalate (24% phthalate, 55 cst), magnesium stearate, anhydrous lactose
FDA label
Avet Pharmaceuticals75 mg, 100 mg, 150 mg, 200 mg

Has lactose

Product page on avetpharma.com

How it looks, what’s in it, NDCs

75 mg White to off white, capsule, 16 mm, marked “I / 15”

Package NDC
Bottle of 60 23155-141-06
Bottle of 100 23155-141-01
Bottle of 500 23155-141-05

100 mg White to off white, capsule, 17 mm, marked “I / 16”

Package NDC
Bottle of 100 23155-142-01
Bottle of 500 23155-142-05

150 mg White to off white, capsule, 19 mm, marked “I / 1 / 7”

Package NDC
Bottle of 60 23155-143-06
Bottle of 100 23155-143-01
Bottle of 250 23155-143-04

200 mg White to off white, oval, 20 mm, marked “I1 / 18”

Package NDC
Bottle of 60 23155-611-06
Bottle of 250 23155-611-04

Inactive ingredients: lactose monohydrate, cellulose, microcrystalline, sodium lauryl sulfate, sodium chloride, hypromellose phthalate (31% phthalate, 40 cst), hypromellose 2910 (5 mpa.s), triethyl citrate, anhydrous lactose, crospovidone (15 mpa.s at 5%), stearic acid, magnesium stearate, hypromellose 2910 (6 mpa.s), triacetin
FDA label
Solco Healthcare50 mg, 150 mg, 200 mg

Has lactose · Made by Prinston Pharmaceutical

Product page on solcohealthcare.com

How it looks, what’s in it, NDCs

50 mg White, oval, 11 mm, marked “P03”

Package NDC
Bottle of 120 43547-462-12

150 mg White, capsule, 19 mm, marked “P / 0 / 1”

Package NDC
Bottle of 60 43547-324-06
Bottle of 100 43547-324-10
Bottle of 500 43547-324-50

200 mg White, oval, 19 mm, marked “P0 / 02”

Package NDC
Bottle of 60 43547-325-06
Bottle of 100 43547-325-10
Bottle of 500 43547-325-50

Inactive ingredients: crospovidone, hypromellose phthalate (31% phthalate, 170 cst), hypromellose, lactose monohydrate, magnesium stearate, mannitol, microcrystalline cellulose, povidone, sodium chloride, sodium lauryl sulfate, talc, triethyl citrate
FDA label

Package	NDC
Bottle of 120	0591-4550-22

Package	NDC
Bottle of 60	0591-4575-60

Package	NDC
Bottle of 60	62332-481-60
Bottle of 100	62332-481-31
Bottle of 1000	62332-481-91

Package	NDC
Bottle of 60	62332-482-60
Bottle of 100	62332-482-31
Bottle of 1000	62332-482-91

Package	NDC
Bottle of 30	62332-483-30
Bottle of 60	62332-483-60
Bottle of 100	62332-483-31
Bottle of 500	62332-483-71

Package	NDC
Bottle of 30	62332-484-30
Bottle of 60	62332-484-60
Bottle of 100	62332-484-31
Bottle of 500	62332-484-71

Package	NDC
Bottle of 60	23155-141-06
Bottle of 100	23155-141-01
Bottle of 500	23155-141-05

Package	NDC
Bottle of 100	23155-142-01
Bottle of 500	23155-142-05

Package	NDC
Bottle of 60	23155-143-06
Bottle of 100	23155-143-01
Bottle of 250	23155-143-04

Package	NDC
Bottle of 60	23155-611-06
Bottle of 250	23155-611-04

Package	NDC
Bottle of 120	43547-462-12

Package	NDC
Bottle of 60	43547-324-06
Bottle of 100	43547-324-10
Bottle of 500	43547-324-50

Package	NDC
Bottle of 60	43547-325-06
Bottle of 100	43547-325-10
Bottle of 500	43547-325-50

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

DORYX MPC is a tetracycline class drug indicated for:

Rickettsial Infections
Sexually Transmitted Infections
Respiratory Tract Infections
Specific Bacterial Infections
Ophthalmic Infections
Anthrax, Including Inhalational Anthrax (Post-Exposure)
Alternative Treatment for Selected Infections when Penicillin is Contraindicated
Adjunctive Therapy in Acute Intestinal Amebiasis and Severe Acne
Prophylaxis of Malaria

Usage

To reduce the development of drug-resistant bacteria and maintain the effectiveness of doxycycline hyclate and other antibacterial drugs, DORYX MPC Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Source: the FDA label for Doryx (Mayne Pharma Commercial LLC), February 16, 2026. Full label on DailyMed

Good to know

It may look different from Doryx (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/doryx/