Efudex

Generic name: fluorouracil

Used for: Actinic keratoses (rough, scaly sun spots) · Superficial basal cell carcinoma (a skin cancer) · 1 more

How do you pay?

How to pay the least

Ask for the cash price

Generic fluorouracil

No pharmacy we check posts a price for it.

  1. Ask your pharmacy for the cash price of generic fluorouracil.Find pharmacies near you 
  2. Ask one or two other pharmacies too. Cash prices for the same generic can differ a lot from store to store.

A regular generic has the same active ingredient as Efudex, and the FDA requires it to work the same way.

Compare every option

Question
Brand nameEfudex
Authorized genericfluorouracil
Regular genericfluorouracil
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Cash priceAsk the pharmacyUsually among the lowest
Cash priceAsk the pharmacyUsually among the lowest
Same as Efudex?
The original
Same medicine
Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Efudex’s maker. Ask the pharmacy for Efudex’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Efudex, without the brand name. Give the pharmacy its NDC to get it.

fluorouracil

Sold by
  • Mylan Pharmaceuticals
NDC to ask for
  • 5%cream
    • 0378-4791-0611-digit: 00378-4791-0640 g per tube

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Efudex, can you tell me what I’d pay for the brand, for the authorized generic from Mylan Pharmaceuticals (NDC 0378-4791-06), and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Efudex doesn’t come in this strength, so there’s no brand label to compare.

Authorized genericMylan Pharmaceuticals
See the ingredients

Active: fluorouracil 0.5%

Inactive:

  • Methylparaben
  • Petrolatum
  • Polysorbate 60
  • Propylene glycol
  • Propylparaben
  • Stearyl alcohol
  • Water

Regular genericWho makes it

5 companies sell a generic of Efudex that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

  • Dr. Reddy’s LaboratoriesCream 5%
    How it looks, what’s in it, NDCs

    5%

    PackageNDC
    Carton of 40 g75907-095-40

    Inactive ingredients: water, petrolatum, cetyl alcohol, stearyl alcohol, propylene glycol, polysorbate 60, propylparaben, methylparaben

    FDA label

  • Encube EthicalsCream 2 g/40 g · Solution 5%
    How it looks, what’s in it, NDCs

    2 g/40 g

    PackageNDC
    Carton of 40 g21922-049-17

    5% White

    PackageNDC
    Carton of 10 mL21922-041-12

    Inactive ingredients: methylparaben, polysorbate 60, propylene glycol, propylparaben, water, stearyl alcohol, petrolatum, edetate disodium, hydroxypropyl cellulose, tromethamine

    FDA label

  • Mayne PharmaCream 5%

    Made by Dr Reddys Laboratories · Being phased out; sold until January 2028

    How it looks, what’s in it, NDCs

    5%

    PackageNDC
    Carton of 40 g51862-362-40

    Inactive ingredients: water, petrolatum, cetyl alcohol, stearyl alcohol, propylene glycol, polysorbate 60, propylparaben, methylparaben

    FDA label

  • NorthStar RxCream 5%

    Made by Taro Pharmaceutical Industries

    Product page on northstarrxllc.com

    How it looks, what’s in it, NDCs

    5% White

    PackageNDC
    Carton of 40 g16714-178-01

    Inactive ingredients: methylparaben, polysorbate 60, propylene glycol, propylparaben, stearyl alcohol, water, white petrolatum

    FDA label

  • Sun Pharmaceutical IndustriesSolution 2%, 5% · Cream 5%

    Made by Taro Pharmaceutical Industries

    How it looks, what’s in it, NDCs

    2%

    PackageNDC
    Carton of 10 mL51672-4062-1

    5%

    PackageNDC
    Carton of 10 mL51672-4063-1

    5% White

    PackageNDC
    Tube of 5 g51672-4118-5
    Carton of 25 g51672-4118-2
    Carton of 40 g51672-4118-6

    Inactive ingredients: edetate disodium, hydroxypropyl cellulose, methylparaben, propylene glycol, propylparaben, tromethamine, water, white petrolatum, stearyl alcohol, polysorbate 60

    FDA label

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

INDICATIONS AND USAGE:

EFUDEX is recommended for the topical treatment of multiple actinic or solar keratoses. In the 5% strength, it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Safety and efficacy in other indications have not been established.

The diagnosis should be established prior to treatment, since this method has not been proven effective in other types of basal cell carcinomas. With isolated, easily accessible basal cell carcinomas, surgery is preferred since success with such lesions is almost 100%. The success rate with EFUDEX Cream and Solution is approximately 93%, based on 113 lesions in 54 patients. Twenty-five lesions treated with the solution produced 1 failure and 88 lesions treated with the cream produced 7 failures.

Source: the FDA label for Efudex (Bausch Health US, LLC), April 23, 2025. Full label on DailyMed 

Good to know

Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/efudex/