Folotyn vs. its authorized generic and generics

Folotyn is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

How to pay the least

Given by your care team

Billed by the clinic

Folotyn is given by a doctor or nurse, not picked up at a pharmacy.

Ask your care team or your plan what you’d pay before your visit.

Compare every option

Brand nameFolotyn

Authorized genericpralatrexate

Regular genericpralatrexate

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Cash priceAsk the pharmacyOften less than Folotyn

Cash priceAsk the pharmacyUsually the lowest

Same as Folotyn?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

Folotyn’s maker has a savings card that lowers what you pay at the pharmacy.

Acrotech Access Support co-pay assistance

Savings card from Acrotech Biopharma

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $25 an infusion

The card takes up to $10,000 a year off your co-pay.

In the maker’s words

“Subsequent Dates of Service: Patient will be responsible for the first $25 of the co-insurance/cost share for the Acrotech product. STAR will cover the remaining cost share for the Acrotech product at 100%.”

From the maker’s offer on acrotechpatientaccess.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericThe NDC to ask for

The same medicine as Folotyn, without the brand name. Give the pharmacy its NDC to get it.

pralatrexate

Sold by

Fresenius Kabi

Given by your care team

This is given by IV at a cancer clinic or hospital, not picked up at a pharmacy.

Your strength

NDC (for your care team)

20 mg/mLinjection
- 65219-550-0111-digit: 65219-0550-011 mL per single-dose vial
40 mg/2 mLinjection
- 65219-552-0211-digit: 65219-0552-022 mL per single-dose vial

Source: FDA, updated October 30, 2026

What to ask your care team

“Which version of Folotyn do you use: the brand, the authorized generic or a regular generic? What would I pay for each?”

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

20 mg/mL injection

Folotyn is sold under its generic name, so there’s no separate brand label to compare. Here’s its label.

Authorized generic package label from Fresenius Kabi — Authorized genericFresenius Kabi

See the ingredients

Active: pralatrexate 20 mg/mL

Inactive:

Hydrochloric acid
Sodium chloride
Sodium hydroxide
Water

40 mg/2 mL injection

Folotyn is sold under its generic name, so there’s no separate brand label to compare. Here’s its label.

See the ingredients

Active: pralatrexate 40 mg/2 mL

Inactive:

Hydrochloric acid
Sodium chloride
Sodium hydroxide
Water

Regular genericWho makes it

One company sells an FDA-rated generic of Folotyn. It’s given by your care team, who choose which one to use.

Dr. Reddy’s LaboratoriesAll 2 strengths

How it looks, what’s in it, NDCs

20 mg/mL

Package NDC
Carton of 1 mL 43598-342-11

40 mg/2 mL

Package NDC
Carton of 2 mL 43598-343-23

Inactive ingredients: sodium chloride, sodium hydroxide, hydrochloric acid, water
FDA label

Package	NDC
Carton of 1 mL	43598-342-11

Package	NDC
Carton of 2 mL	43598-343-23

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

Peripheral T-cell lymphoma (PTCL)

What the FDA label says

FOLOTYN is a dihydrofolate reductase inhibitor indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). This indication is approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).

Source: the FDA label for Folotyn (Acrotech Biopharma Inc), September 16, 2026. Full label on DailyMed

Good to know

It may look different from Folotyn (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Coverage depends on your plan. Your care team or insurer can tell you what you’d pay.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/folotyn/