Hydrea savings card: as little as $10 a prescription with commercial insurance

How to pay the least

Lowest without a membership

$12 for 30 capsules

Generic hydroxyurea 500 mg from Rx Outreach, by mail

Make a free account on rxoutreach.org. Ask your prescriber to send the prescription there, or Rx Outreach can transfer it.Open Rx Outreach
Order generic hydroxyurea 500 mg. It comes by mail.

Need it today? $17.38 for 30 capsules with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.

See the price and get the card

For 3 months at a time $22 for 90 capsules from Rx Outreach, by mail. Ask your prescriber to write it for 90 days.

Open Rx Outreach

With a membership $7.40 for 30 capsules from Amazon Pharmacy, by mail ($139 a year).

Open Amazon Pharmacy

A regular generic has the same active ingredient as Hydrea, and the FDA requires it to work the same way.

Compare every option

Brand nameHydrea

Authorized generichydroxyurea

Regular generichydroxyurea

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Not soldThere isn’t one

Lowest$12for 30 capsules at Rx OutreachWith a membership: $7.40 at Amazon Pharmacy

Same as Hydrea?

The original

–

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

HYDREA Copay Savings Program (Waylis Patient Access and Affordability)

Savings card from Waylis Therapeutics

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $10 a prescription

Or call 1-888-218-8897.

In the maker’s words

“Eligible patients may pay as little as $10.00 for your prescription. Annual, monthly, and per-fill program limits apply.”

From the maker’s offer on hydrearx.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Brand nameWith a free discount coupon

Optum Perks, Optum’s free discount coupon, lists these prices for Hydrea without insurance. Show the coupon from its page at the pharmacy; it can’t be used with insurance.

Pick up in store: Walgreens $473for 45 capsules500 mg

From Optum Perks, read November 2, 2026, with no location set. Its page opens on this dose; other doses and pharmacies near you are priced there too. With insurance, check your co-pay first: it may be lower.

Authorized genericNot sold

There isn’t one. An authorized generic is Hydrea itself, from the same company, sold without the brand name, and usually for less. A regular generic is sold, with the same active ingredient: ask the pharmacy for its price.

See the regular generic →

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic hydroxyurea, lowest first.

Pick up in storeDelivered

Delivered: Amazon Pharmacy $7.40for 30 capsules500 mgPrime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
Delivered: Cost Plus Drugs $8.24for 30 capsules500 mgPlus $5.25 shipping
Pick up in store: Costco $33.79for 90 capsules500 mgMembers only · $65 a yearFind the nearest store
Delivered: Costco $33.79for 90 capsules500 mgMembers only · $65 a year · Plus shipping
Delivered: Rx Outreach $12for 30 capsules500 mg90 capsules: $22Free delivery
Pick up in store: Team Cuban Card $17.38for 30 capsules500 mgFree card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

4 companies sell a generic of Hydrea that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Leading Pharma500 mg

Has lactose · Has dyes: D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 3

How it looks, what’s in it, NDCs

500 mg Cap-opaque green and body-opaque light pink, capsule, 22 mm, marked “LP / 164”

Package NDC
Bottle of 100 69315-164-01

Inactive ingredients: D&C Yellow No. 10, FD&C Red No. 3, FD&C Blue No. 1, gelatin, anhydrous lactose, magnesium stearate, silicon dioxide, titanium dioxide
FDA label
Par Health500 mg

Has dyes: D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 40 · Made by PH Health

How it looks, what’s in it, NDCs

500 mg Dark Green and Pink, capsule, 19 mm, marked “724 / par”

Package NDC
Bottle of 100 49884-724-01

Inactive ingredients: silicon dioxide, D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, titanium dioxide
FDA label
Somerset Therapeutics500 mg

Has dyes: FD&C Blue No. 1, FD&C Red No. 3 · Made by Qilu Pharmaceutical

Product page on somersetpharma.com

How it looks, what’s in it, NDCs

500 mg Opaque pink body and opaque powder blue cap, capsule, 22 mm, marked “83”

Package NDC
Bottle of 100 70069-820-01

Inactive ingredients: silicon dioxide, magnesium stearate, gelatin, titanium dioxide, FD&C Red No. 3, FD&C Blue No. 1, shellac, ferrosoferric oxide, potassium hydroxide
FDA label
Teva Pharmaceuticals500 mg

Has lactose · Has dyes: D&C Red No. 28, D&C Yellow No. 10 aluminum lake, FD&C Blue No. 1, FD&C Blue No. 1 aluminum lake, FD&C Blue No. 2--aluminum lake, FD&C Red No. 40 · Made by Barr

How it looks, what’s in it, NDCs

500 mg Purple and pink, capsule, 22 mm, marked “barr / 882”

Package NDC
Bottle of 100 0555-0882-02

Inactive ingredients: anhydrous citric acid, ferrosoferric oxide, D&C Red No. 28, D&C Yellow No. 10 aluminum lake, sodium phosphate, dibasic, anhydrous, FD&C Blue No. 1, FD&C Blue No. 1 aluminum lake, FD&C Blue No. 2--aluminum lake, FD&C Red No. 40, gelatin, lactose monohydrate, magnesium stearate, propylene glycol, ferric oxide red, shellac, sodium lauryl sulfate, titanium dioxide
FDA label

Package	NDC
Bottle of 100	69315-164-01

Package	NDC
Bottle of 100	49884-724-01

Package	NDC
Bottle of 100	70069-820-01

Package	NDC
Bottle of 100	0555-0882-02

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What to say at the pharmacy

“Before you fill my Hydrea, can you tell me what I’d pay for the brand and for a generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

What it’s used for

What the FDA label says

HYDREA is an antimetabolite indicated for the treatment of:

Resistant chronic myeloid leukemia.
Locally advanced squamous cell carcinomas of the head and neck, (excluding lip) in combination with concurrent chemoradiation.

Source: the FDA label for Hydrea (H2-Pharma LLC), January 26, 2026. Full label on DailyMed

Good to know

A regular generic may look different from Hydrea. The FDA requires it to work the same way.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/hydrea/