Kalydeco savings card: as little as $0 a fill with commercial insurance

How to pay the least

Ask for the cash price

Kalydeco

We didn’t find one.

Ask your pharmacy for Kalydeco’s cash price, and one or two other pharmacies too.
Kalydeco’s savings card works only with insurance from a job or one you bought.

Compare every option

Brand nameKalydeco

Authorized genericivacaftor

Regular genericivacaftor

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldNone found

Same as Kalydeco?

The original

–

Brand nameThe maker’s card

Vertex GPS Co-pay Assistance Program

Savings card from Vertex Pharmaceuticals

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $0 a fill

The card takes up to $20,000 a year off your co-pay.

Or call 1-877-752-5933.

In the maker’s words

“the Vertex GPS Co-pay Assistance Program may be able to lower your co-pay to as little as $0 per fill.”

From the maker’s offer on kalydeco.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Kalydeco itself, from the same company, sold without the brand name, and usually for less. For now Kalydeco is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

We didn’t find one. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Cystic fibrosis (CF) with certain CFTR gene changes

What the FDA label says

KALYDECO is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator indicated for the treatment of cystic fibrosis (CF) in patients aged 1 month and older who have at least one mutation in the CFTR gene that is responsive to ivacaftor based on clinical and/or in vitro assay data.

If the patient's genotype is unknown, an FDA-cleared CF mutation test should be used to detect the presence of a CFTR mutation followed by verification with bi-directional sequencing when recommended by the mutation test instructions for use.

Source: the FDA label for Kalydeco (Vertex Pharmaceuticals Incorporated), March 23, 2026. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/kalydeco/