Lomotil vs. its authorized generic and generics

How to pay the least

Ask for the cash price

Generic diphenoxylate and atropine

Only Amazon Pharmacy posts a price for diphenoxylate and atropine 2.5 mg / 0.025 mg, 30 tablets, and it’s for members. Pharmacies pay about $4.28 for 30 tablets; cash prices are higher. Ask two or three.

Ask your pharmacy: “What’s your cash price for generic diphenoxylate and atropine 2.5 mg / 0.025 mg, 30 tablets?”Find pharmacies near you
Ask one or two other pharmacies too. Cash prices for the same generic can differ a lot from store to store.

With a membership $5 for 30 tablets from Amazon Pharmacy, by mail ($139 a year).

Open Amazon Pharmacy

Has to be Lomotil? With Optum Perks’ free coupon, Walgreens lists it for $8.14 for 30 tablets without insurance.

Get the free Optum Perks coupon

A regular generic has the same active ingredient as Lomotil, and the FDA requires it to work the same way.

Compare every option

Brand nameLomotil

Authorized genericdiphenoxylate and atropine

Regular genericdiphenoxylate and atropine

What you’d pay

At least$89for 30 tablets; pharmacies pay this

Cash priceAsk the pharmacyUsually among the lowest

Cash priceMembers only$5 for 30 tablets at Amazon Pharmacy

Same as Lomotil?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameWith a free discount coupon

Optum Perks, Optum’s free discount coupon, lists these prices for Lomotil without insurance. Show the coupon from its page at the pharmacy; it can’t be used with insurance.

Pick up in store: Walgreens $8.14for 30 tablets2.5/0.025 mg
Pick up in store: CVS Pharmacy $14for 30 tablets2.5/0.025 mg

From Optum Perks, read November 2, 2026, with no location set. Its page opens on this dose; other doses and pharmacies near you are priced there too. With insurance, check your co-pay first: it may be lower.

Authorized genericThe NDC to ask for

The same medicine as Lomotil, without the brand name. Give the pharmacy its NDC to get it.

diphenoxylate and atropine

Sold by

Mylan Pharmaceuticals

NDC to ask for

2.5 mg / 0.025 mgtablet
- 59762-1061-111-digit: 59762-1061-01100 tablets per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Lomotil, can you tell me what I’d pay for the brand, for the authorized generic from Mylan Pharmaceuticals (NDC 59762-1061-1), and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Same active and inactive ingredients as Lomotil.

Authorized generic package label from Mylan Pharmaceuticals — Authorized genericMylan Pharmaceuticals

See the ingredients

Active: diphenoxylate hydrochloride 2.5 mg · atropine sulfate 0.025 mg

Inactive, on both labels:

Acacia
Magnesium stearate
Sorbitol
Corn starch
Sucrose
Talc

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic diphenoxylate and atropine, lowest first.

Pick up in storeDelivered

Delivered: Amazon Pharmacy $5for 30 tablets2.5 mg / 0.025 mgPrime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
Pick up in store: Costco $33.99for 60 tablets2.5 mg / 0.025 mgMembers only · $65 a yearFind the nearest store

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

5 companies sell a generic of Lomotil that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

ANI Pharmaceuticals2.5 mg / 0.025 mg

Has lactose

Product page on anipharmaceuticals.com

How it looks, what’s in it, NDCs

2.5 mg / 0.025 mg White, round, 6 mm, marked “490”

Package NDC
Bottle of 100 62559-490-01
Bottle of 1000 62559-490-10

Inactive ingredients: lactose monohydrate, starch, corn, sodium starch glycolate type a potato, silicon dioxide, magnesium stearate, microcrystalline cellulose
FDA label
Leading Pharma2.5 mg / 0.025 mg

Has lactose

How it looks, what’s in it, NDCs

2.5 mg / 0.025 mg White to off white, round, 6 mm, marked “LP / 910”

Package NDC
Bottle of 90 69315-910-09
Bottle of 100 69315-910-01
Bottle of 1000 69315-910-10

Inactive ingredients: silicon dioxide, lactose monohydrate, microcrystalline cellulose, starch, corn, stearic acid
FDA label
SpecGx2.5 mg / 0.025 mg

How it looks, what’s in it, NDCs

2.5 mg / 0.025 mg White, round, 6 mm, marked “M”

Package NDC
Bottle of 100 0406-1236-01
Bottle of 1000 0406-1236-10

Inactive ingredients: starch, corn, magnesium stearate, microcrystalline cellulose
FDA label
Unichem Pharmaceuticals2.5 mg / 0.025 mg

Product page on unichemusa.com

How it looks, what’s in it, NDCs

2.5 mg / 0.025 mg White, round, 6 mm, marked “BY3 / ”

Package NDC
Bottle of 100 76385-107-01
Bottle of 1000 76385-107-10

Inactive ingredients: mannitol, starch, corn, hypromellose, silicon dioxide, magnesium stearate
FDA label
Winder Laboratories2.5 mg / 0.025 mg

How it looks, what’s in it, NDCs

2.5 mg / 0.025 mg White, round, 6 mm, marked “WL / 107”

Package NDC
Bottle of 10 75826-107-11
Bottle of 30 75826-107-33
Bottle of 90 75826-107-90
Bottle of 100 75826-107-03
Bottle of 1000 75826-107-00

Inactive ingredients: microcrystalline cellulose, starch, corn, silicon dioxide, stearic acid
FDA label

Package	NDC
Bottle of 100	62559-490-01
Bottle of 1000	62559-490-10

Package	NDC
Bottle of 90	69315-910-09
Bottle of 100	69315-910-01
Bottle of 1000	69315-910-10

Package	NDC
Bottle of 100	0406-1236-01
Bottle of 1000	0406-1236-10

Package	NDC
Bottle of 100	76385-107-01
Bottle of 1000	76385-107-10

Package	NDC
Bottle of 10	75826-107-11
Bottle of 30	75826-107-33
Bottle of 90	75826-107-90
Bottle of 100	75826-107-03
Bottle of 1000	75826-107-00

The FDA doesn’t rate Hikma Pharmaceuticals’s version of diphenoxylate and atropine a substitute for Lomotil, so a pharmacy can’t swap it in without your prescriber’s OK.

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

Diarrhea

What the FDA label says

Lomotil is indicated as adjunctive therapy in the management of diarrhea in patients 13 years of age and older.

Source: the FDA label for Lomotil (Pfizer Laboratories Div Pfizer Inc), February 23, 2026. Full label on DailyMed

Good to know

It may look different from Lomotil (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/lomotil/