An authorized generic of Lotronex was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (alosetron hydrochloride) is available.
Source: FDA, updated October 30, 2026
How to pay the least
From
$35.53 for 30 tablets delivered ($30.28 plus $5.25 shipping)
Generic alosetron from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.
- Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
- Order generic alosetron. It comes by mail.
Need it today? From $49.86 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.
See the price and get the cardA regular generic has the same active ingredient as Lotronex, and the FDA requires it to work the same way.
Compare every option
Question
Brand nameLotronex
Authorized genericalosetron
Regular genericalosetron
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Not soldNo longer sold
Same as Lotronex?
The original
–
Same active ingredientFillers and dyes can differ
Details for each option
Details for
Brand nameNo maker’s card
We didn’t find a savings card or cash price from Lotronex’s maker. Ask the pharmacy for Lotronex’s cash price. With insurance, ask what your plan charges.
Authorized genericNot sold now
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic alosetron, lowest first.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs from $30.28for 30 tablets0.5 mg $30.28 · 1 mg $47.07Plus $5.25 shipping
- Pick up in store: CVS Pharmacy + Optum Perks $70.81for 60 tablets0.5 mgFree Optum Perks coupon · not with insuranceFind the nearest store
- Pick up in store: Team Cuban Card from $49.86for 30 tablets0.5 mg $49.86 · 1 mg $62.90Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
- Pick up in store: Costco $141.79for 30 tablets1 mgMembers only · $65 a yearFind the nearest store
- Delivered: Costco $141.79for 30 tablets1 mgMembers only · $65 a year · Plus shipping
- Delivered: Amazon Pharmacy from $178.10for 30 tablets0.5 mg $178.10 · 1 mg $353.90Prime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
- Pick up in store: Walgreens + Optum Perks $433for 60 tablets0.5 mgFree Optum Perks coupon · not with insuranceFind the nearest store
- Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
About these prices
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
2 companies sell a generic of Lotronex that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
-
Amneal PharmaceuticalsAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2
How it looks, what’s in it, NDCs
0.5 mg White, oval, 11 mm, marked “AN248”
Package NDC Bottle of 30 53746-248-30 0.5 mg White, oval, 11 mm, marked “AN248”
Package NDC Bottle of 30 65162-248-03 Bottle of 500 65162-248-50 1 mg Light blue, oval, 11 mm, marked “AN249”
Package NDC Bottle of 30 53746-249-30 1 mg Light blue, oval, 11 mm, marked “AN249”
Package NDC Bottle of 30 65162-249-03 Bottle of 500 65162-249-50 Inactive ingredients: lactose monohydrate, magnesium stearate, cellulose, microcrystalline, starch, corn, hypromelloses, polyethylene glycol, polysorbate 80, titanium dioxide, FD&C Blue No. 2
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Eywa PharmaAll 2 strengths
Has lactose · Made by Adaptis Pharma
How it looks, what’s in it, NDCs
0.5 mg White, oval, 11 mm, marked “E / 3”
Package NDC Bottle of 30 71930-010-30 1 mg White, oval, 11 mm, marked “E / 4”
Package NDC Bottle of 30 71930-011-30 Inactive ingredients: anhydrous lactose, magnesium stearate, cellulose, microcrystalline, starch, corn, hypromellose 2910 (6 mpa.s), titanium dioxide, triacetin, polyethylene glycol
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What it’s used for
What the FDA label says
LOTRONEX is a selective serotonin 5-HT 3antagonist indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have:
- chronic IBS symptoms (generally lasting 6 months or longer),
- had anatomic or biochemical abnormalities of the gastrointestinal tract excluded, and
- not responded adequately to conventional therapy.
Severe IBS includes diarrhea and 1 or more of the following:
- frequent and severe abdominal pain/discomfort,
- frequent bowel urgency or fecal incontinence,
- disability or restriction of daily activities due to IBS.
Source: the FDA label for Lotronex (Sebela Pharmaceuticals Inc.), June 30, 2026. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/lotronex/