Match the strength and how many to your prescription label.
How to pay the least
Lowest price
$12.94 for 30 tablets delivered: $7.69 plus $5.25 shipping
Generic methotrexate 2.5 mg from Cost Plus Drugs, by mail
- Make a free account on costplusdrugs.com, and ask your prescriber to send the prescription there. Already sent to a pharmacy? Cost Plus Drugs can ask that pharmacy to transfer it.Open Cost Plus Drugs
- Order generic methotrexate 2.5 mg: $7.69 for 30 tablets, plus $5.25 shipping. It comes by mail.
Need it today? $15.70 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card, then show it at a pharmacy that takes it.
See the price and get the cardEvery company’s methotrexate is rated by the FDA to work the same, so any pharmacy can fill your prescription with the one it stocks.
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic methotrexate, lowest first. Any of them can fill your prescription.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs $7.69for 30 tablets2.5 mgPlus $5.25 shipping
- Pick up in store: Costco $10.99for 24 tablets2.5 mgMembers only · $65 a yearFind the nearest store
- Pick up in store: Team Cuban Card $15.70for 30 tablets2.5 mgFree card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
- Delivered: Costco $13.98for 24 tablets2.5 mgMembers only · $65 a year · Plus shipping
- Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store
From each pharmacy’s own site, read October 5, 2026. Confirm the price before you fill. Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
11 companies sell methotrexate in this form, each one rated by the FDA as a substitute for the others. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
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Accord Healthcare2.5 mg
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Alembic Pharmaceuticals2.5 mg
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Aurobindo Pharma2.5 mg
Made by Eugia Pharma Specialities
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Chartwell RX2.5 mg
Made by Eugia Pharma Specialities
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Elite Laboratories2.5 mg
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Hikma Pharmaceuticals2.5 mg
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Mylan Institutional2.5 mg
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Mylan Pharmaceuticals2.5 mg
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Sun Pharmaceutical Industries2.5 mg
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Teva Pharmaceuticals2.5 mg
Made by Barr
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Zydus Lifesciences2.5 mg
Packages and NDCs
2.5 mg
Package NDC Bottle of 36 68382-775-60 Bottle of 90 68382-775-16 Bottle of 100 68382-775-01 Carton of 100 68382-775-77 Bottle of 500 68382-775-05 Bottle of 1000 68382-775-10
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What to say at the pharmacy
“Before you fill it, what would I pay for generic methotrexate?”
Paying cash? Ask for the cash price. With insurance, ask what your plan charges.
Good to know
- Different companies’ methotrexate can look different. The FDA requires each to work the same way.
- Don’t stop or change a medicine without talking to your pharmacist or prescriber.