Naprelan

Generic name: naproxen

Used for: Pain · Osteoarthritis (wear-and-tear arthritis) · Rheumatoid arthritis · Menstrual cramps · Gout attacks · Tendonitis and bursitis · Ankylosing spondylitis (arthritis of the spine) · 6 more

How do you pay?

How to pay the least

From

$173.68 for 30 tablets delivered ($168.43 plus $5.25 shipping)

Generic naproxen ER from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.

  1. Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs 
  2. Order generic naproxen ER. It comes by mail.

Sold without a prescription Naproxen ER is also sold over the counter (220 mg: Aleve and store brands). Ask your pharmacist or prescriber whether it would do for you.

A regular generic has the same active ingredient as Naprelan, and the FDA requires it to work the same way.

Compare every option

Question
Brand nameNaprelan
Authorized genericnaproxen
Regular genericnaproxen
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Cash priceAsk the pharmacyUsually among the lowest
From$173.68for 30 tablets at Cost Plus Drugs, with shipping
Same as Naprelan?
The original
Same medicine
Same active ingredientFillers and dyes can differ

Brand nameWith a free discount coupon

Optum Perks, Optum’s free discount coupon, lists these prices for Naprelan without insurance. Show the coupon from its page at the pharmacy; it can’t be used with insurance.

From Optum Perks, read November 2, 2026, with no location set. Its page opens on this dose; other doses and pharmacies near you are priced there too. With insurance, check your co-pay first: it may be lower.

Authorized genericThe NDC to ask for

The same medicine as Naprelan, without the brand name. Give the pharmacy its NDC to get it.

naproxen

Sold by (either works)
  • Upsher-Smith LaboratoriesThe company behind Naprelan
  • Alvogen
  • SA3
Your strength
NDC to ask for
  • 375 mgextended-release tabletAlvogen
    • 47781-153-0111-digit: 47781-0153-01100 tablets per bottle
  • 375 mgextended-release tabletSA3
    • 69420-1375-111-digit: 69420-1375-01100 tablets per bottle
  • 375 mgextended-release tabletUpsher-Smith Laboratories
    • 24979-252-0111-digit: 24979-0252-01100 tablets per bottle
  • 500 mgextended-release tabletAlvogen
    • 47781-154-7511-digit: 47781-0154-7575 tablets per bottle
  • 500 mgextended-release tabletUpsher-Smith Laboratories
    • 24979-253-6811-digit: 24979-0253-6875 tablets per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Naprelan, can you tell me what I’d pay for the brand, for the authorized generic, and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

375 mg extended-release tablet · Alvogen

Same active and inactive ingredients as Naprelan.

See the ingredients

Active: naproxen sodium 375 mg

Inactive, on both labels:

  • Ammonio methacrylate copolymer type A
  • Ammonio methacrylate copolymer type B
  • Anhydrous citric acid
  • Crospovidone
  • Hypromellose
  • Magnesium stearate
  • Methacrylic acid - methyl methacrylate copolymer
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Povidone
  • Talc
  • Titanium dioxide

500 mg extended-release tablet · Alvogen

Same active and inactive ingredients as Naprelan.

See the ingredients

Active: naproxen sodium 500 mg

Inactive, on both labels:

  • Ammonio methacrylate copolymer type A
  • Ammonio methacrylate copolymer type B
  • Anhydrous citric acid
  • Crospovidone
  • Hypromellose
  • Magnesium stearate
  • Methacrylic acid - methyl methacrylate copolymer
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Povidone
  • Talc
  • Titanium dioxide

375 mg extended-release tablet · SA3

Same active and inactive ingredients as Naprelan.

Authorized genericSA3
See the ingredients

Active: naproxen sodium 375 mg

Inactive, on both labels:

  • Ammonio methacrylate copolymer type A
  • Ammonio methacrylate copolymer type B
  • Citric acid monohydrate
  • Crospovidone
  • Hypromellose
  • Magnesium stearate
  • Methacrylic acid - methyl methacrylate copolymer
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Povidone
  • Talc
  • Titanium dioxide

375 mg extended-release tablet · Upsher-Smith Laboratories

Same active and inactive ingredients as Naprelan.

Authorized genericUpsher-Smith Laboratories
See the ingredients

Active: naproxen sodium 375 mg

Inactive, on both labels:

  • Ammonio methacrylate copolymer type A
  • Ammonio methacrylate copolymer type B
  • Anhydrous citric acid
  • Crospovidone
  • Hypromellose
  • Magnesium stearate
  • Methacrylic acid - methyl methacrylate copolymer
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Povidone
  • Talc
  • Titanium dioxide

500 mg extended-release tablet · Upsher-Smith Laboratories

Same active and inactive ingredients as Naprelan.

Authorized genericUpsher-Smith Laboratories
See the ingredients

Active: naproxen sodium 500 mg

Inactive, on both labels:

  • Ammonio methacrylate copolymer type A
  • Ammonio methacrylate copolymer type B
  • Anhydrous citric acid
  • Crospovidone
  • Hypromellose
  • Magnesium stearate
  • Methacrylic acid - methyl methacrylate copolymer
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Povidone
  • Talc
  • Titanium dioxide

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic naproxen, lowest first.

Delivered

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

One company sells a generic of Naprelan that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

  • Teva PharmaceuticalsAll 3 strengths

    Made by Actavis Laboratories FL

    Packages and NDCs

    375 mg White, round, 11 mm, marked “Andrx / 825”

    PackageNDC
    Bottle of 1000480-0951-01

    500 mg White, oval, 17 mm, marked “Andrx / 826”

    PackageNDC
    Bottle of 750480-0952-58

    750 mg White, oval, 22 mm, marked “A750”

    PackageNDC
    Bottle of 300480-0953-56

    FDA label

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

NAPRELAN is a nonsteroidal anti-inflammatory drug indicated for the treatment of:

  • rheumatoid arthritis (RA) • osteoarthritis (OA) • ankylosing spondylitis (AS) • tendinitis, bursitis • acute gout • primary dysmenorrhea (PD) • the relief of mild to moderate pain

Source: the FDA label for Naprelan (Upsher-Smith Laboratories, LLC), January 8, 2026. Full label on DailyMed 

Good to know

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/naprelan/