Neoprofen vs. its authorized generic and generics

Neoprofen is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

How to pay the least

Given by your care team

Billed by the clinic

Neoprofen is given by a doctor or nurse, not picked up at a pharmacy.

Ask your care team or your plan what you’d pay before your visit.

Compare every option

Brand nameNeoprofen

Authorized genericibuprofen lysine

Regular genericibuprofen lysine

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Cash priceAsk the pharmacyOften less than Neoprofen

Cash priceAsk the pharmacyUsually the lowest

Same as Neoprofen?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Neoprofen’s maker. Ask the pharmacy for Neoprofen’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Neoprofen, without the brand name. Give the pharmacy its NDC to get it.

ibuprofen lysine

Sold by

Prasco LaboratoriesMade by Alcami Carolinas, which also makes Neoprofen

Given by your care team

This is given in the hospital to premature babies, not picked up at a pharmacy.

NDC (for your care team)

10 mg/mLsolution
- 66993-490-3611-digit: 66993-0490-363 vials, 2 mL each

Source: FDA, updated October 30, 2026

What to ask your care team

“Which version of Neoprofen do you use: the brand, the authorized generic or a regular generic? What would I pay for each?”

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Same active and inactive ingredients as Neoprofen.

Neoprofen package label — BrandNeoprofen

Authorized generic package label from Prasco Laboratories — Authorized genericPrasco Laboratories

See the ingredients

Active: ibuprofen lysine 10 mg/mL

Inactive, on both labels:

Water

Regular genericWho makes it

One company sells an FDA-rated generic of Neoprofen. It’s given by your care team, who choose which one to use.

XGen Pharmaceuticals DJB10 mg/mL

Product page on xgenpharmadjb.com

How it looks, what’s in it, NDCs

10 mg/mL

Package NDC
Carton of 6 mL 39822-1030-2

Inactive ingredients: water
FDA label

Package	NDC
Carton of 6 mL	39822-1030-2

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

Closing an open heart vessel (PDA) in premature babies

What the FDA label says

NeoProfen is a nonsteroidal anti-inflammatory drug indicated to close a clinically significant patent ductus arteriosus (PDA) in premature infants weighing between 500 and 1500 g, who are no more than 32 weeks gestational age when usual medical management is ineffective. The clinical trial was conducted among infants with an asymptomatic PDA. However, the consequences beyond 8 weeks after treatment have not been evaluated; therefore, treatment should be reserved for infants with clear evidence of a clinically significant PDA.

Source: the FDA label for Neoprofen (Recordati Rare Diseases Inc.), October 15, 2024. Full label on DailyMed

Good to know

It may look different from Neoprofen (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Coverage depends on your plan. Your care team or insurer can tell you what you’d pay.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/neoprofen/