Odefsey savings card: as little as $0 a month with commercial insurance

How to pay the least

Cash price

$3,910+ for 30 tablets

Pharmacies pay about this for Odefsey; you’d pay more.

Ask your pharmacy for Odefsey’s cash price, and one or two other pharmacies too.
Odefsey’s savings card works only with insurance from a job or one you bought.

Free from the maker, if you qualify Advancing Access Patient Assistance Program/Medication Assistance Program (PAP/MAP). Or call 1-800-226-2056.

See if you qualify

No generic is sold yet.

Compare every option

Brand nameOdefsey

Authorized genericemtricitabine, rilpivirine, and tenofovir alafenamide

Regular genericemtricitabine, rilpivirine, and tenofovir alafenamide

What you’d pay

At least$3,910for 30 tablets; pharmacies pay this

Not soldThere isn’t one

Not soldNone sold yet

Same as Odefsey?

The original

–

Brand nameThe maker’s card

Gilead Advancing Access Co-pay Savings Program

Savings card from Gilead Sciences

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $0 a month

Or call 1-866-664-5327.

In the maker’s words

“Eligible patients could pay as little as $0 per month.”

From the maker’s offer on gilead.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Odefsey itself, from the same company, sold without the brand name, and usually for less. For now Odefsey is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

No generic is sold yet. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

What the FDA label says

ODEFSEY is a three-drug combination of emtricitabine (FTC) and tenofovir alafenamide (TAF), both HIV nucleoside analog reverse transcriptase inhibitors (NRTIs), and rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), and is indicated as a complete regimen for the treatment of HIV-1 infection in adult and pediatric patients weighing at least 25kg:

as initial therapy in those with no antiretroviral treatment history with HIV-1 RNA less than or equal to 100,000 copies/mL; or
to replace a stable antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies/mL) for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components of ODEFSEY.

Limitations of Use:

More rilpivirine-treated participants with HIV-1 RNA greater than 100,000 copies/mL at the start of therapy experienced virologic failure (HIV-1 RNA ≥ 50 copies/mL) compared to rilpivirine-treated participants with HIV-1 RNA less than or equal to 100,000 copies/mL.

Source: the FDA label for Odefsey (Gilead Sciences, Inc.), December 2, 2025. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/odefsey/