Opsynvi savings card: as little as $5 a fill with commercial insurance

How to pay the least

Ask for the cash price

Opsynvi

We didn’t find one.

Ask your pharmacy for Opsynvi’s cash price, and one or two other pharmacies too.
Opsynvi’s savings card works only with insurance from a job or one you bought.

Free from the maker, if you qualify Johnson & Johnson Patient Assistance Program (pulmonary hypertension medicines). Patients’ income must be equal to or less than 300% of Federal Poverty Level (FPL). Or call 1-833-742-0791.

See if you qualify

Compare every option

Brand nameOpsynvi

Authorized genericmacitentan and tadalafil

Regular genericmacitentan and tadalafil

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldNone found

Same as Opsynvi?

The original

–

Brand nameThe maker’s card

J&J withMe Oral PAH Savings Program

Savings card from Johnson & Johnson

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $5 a fill

Or call 1-833-742-0791.

In the maker’s words

“Eligible patients pay $5 per prescription fill.”

From the maker’s offer on jnjwithme.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Opsynvi itself, from the same company, sold without the brand name, and usually for less. For now Opsynvi is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

We didn’t find one. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

High blood pressure in the lungs (PAH)

What the FDA label says

OPSYNVI is a combination of macitentan, an endothelin receptor antagonist (ERA), and tadalafil, a phosphodiesterase 5 (PDE5) inhibitor, indicated for chronic treatment of pulmonary arterial hypertension (PAH, WHO Group I) in adult patients of WHO functional class (FC) II–III.

Individually, macitentan reduces the risk of clinical worsening events and hospitalization, and tadalafil improves exercise ability.

Source: the FDA label for Opsynvi (Actelion Pharmaceuticals US, Inc.), April 11, 2025. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/opsynvi/