Orkambi savings card: as little as $0 a fill with commercial insurance

How to pay the least

Ask for the cash price

Orkambi

We didn’t find one.

Ask your pharmacy for Orkambi’s cash price, and one or two other pharmacies too.
Orkambi’s savings card works only with insurance from a job or one you bought.

Compare every option

Brand nameOrkambi

Authorized genericlumacaftor and ivacaftor

Regular genericlumacaftor and ivacaftor

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldNone found

Same as Orkambi?

The original

–

Brand nameThe maker’s card

Vertex GPS Co-pay Assistance Program

Savings card from Vertex Pharmaceuticals

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $0 a fill

The card takes up to $20,000 a year off your co-pay.

Or call 1-877-752-5933.

In the maker’s words

“the Vertex GPS Co-pay Assistance Program may be able to lower your co-pay to as little as $0 per fill.”

From the maker’s offer on orkambi.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Orkambi itself, from the same company, sold without the brand name, and usually for less. For now Orkambi is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

We didn’t find one. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Cystic fibrosis with two copies of the F508del mutation

What the FDA label says

ORKAMBI is a combination of ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, and lumacaftor, indicated for the treatment of cystic fibrosis (CF) in patients aged 1 year and older who are homozygous for the F508del mutation in the CFTR gene. If the patient's genotype is unknown, an FDA-cleared CF mutation test should be used to detect the presence of the F508del mutation on both alleles of the CFTR gene.

Limitations of Use:

The efficacy and safety of ORKAMBI have not been established in patients with CF other than those homozygous for the F508del mutation.

Source: the FDA label for Orkambi (Vertex Pharmaceuticals Incorporated), March 24, 2026. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/orkambi/