Orladeyo savings card: as little as $0 a month with commercial insurance

How to pay the least

Ask for the cash price

Orladeyo

We didn’t find one.

Ask your pharmacy for Orladeyo’s cash price, and one or two other pharmacies too.
Orladeyo’s savings card works only with insurance from a job or one you bought.

Compare every option

Brand nameOrladeyo

Authorized genericberotralstat

Regular genericberotralstat

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldNone found

Same as Orladeyo?

The original

–

Brand nameThe maker’s card

ORLADEYO Empower Patient Services Copay Assistance Program

Savings card from BioCryst Pharmaceuticals

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $0 a month

Or call 1-866-536-7693.

In the maker’s words

“Pay as little as $0 for treatmenta…”

From the maker’s offer on orladeyo.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Orladeyo itself, from the same company, sold without the brand name, and usually for less. For now Orladeyo is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

We didn’t find one. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Preventing swelling attacks of hereditary angioedema (HAE)

What the FDA label says

ORLADEYO is a plasma kallikrein inhibitor indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 2 years and older.

Limitations of Use:

ORLADEYO should not be used for treatment of acute HAE attacks.

Source: the FDA label for Orladeyo (BioCryst Pharmaceuticals, Inc.), August 20, 2026. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/orladeyo/