Otrexup savings card: up to $250 off a fill with commercial insurance

How to pay the least

Ask for the cash price

Otrexup

Sold only in a different form, strength or formula. Switching to one would need a new prescription, so ask your prescriber whether it could work for you.

Ask your pharmacy for Otrexup’s cash price, and one or two other pharmacies too.
Otrexup’s savings card works only with insurance from a job or one you bought.

Compare every option

Brand nameOtrexup

Authorized genericmethotrexate

Regular genericmethotrexate

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Other forms onlyAsk your doctor

Same as Otrexup?

The original

–

Brand nameThe maker’s card

Otrexup Total Care Co-Pay Assistance Program

Savings card from Antares Pharma

No insuranceNeeds insuranceNo cash price listed.

Insurance · up to $250 off a fill

In the maker’s words

“To receive co-pay assistance of up to $250 for each prescription filled, please accurately answer the questions below:”

From the maker’s offer on sservices.trialcard.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Otrexup itself, from the same company, sold without the brand name, and usually for less. For now Otrexup is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

Sold only in a different form, strength or formula. Switching to one would need a new prescription, so ask your prescriber whether it could work for you. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

What the FDA label says

Otrexup is a folate analog metabolic inhibitor indicated for the:

Management of patients with severe, active rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (pJIA), who are intolerant of or had an inadequate response to first-line therapy.
Symptomatic control of severe, recalcitrant, disabling psoriasis in adults who are not adequately responsive to other forms of therapy.

Limitation of Use

Otrexup is not indicated for the treatment of neoplastic diseases.

Source: the FDA label for Otrexup (Antares Pharma, Inc.), January 31, 2025. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/otrexup/