An authorized generic of Plaquenil was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (hydroxychloroquine sulfate) is available.
Source: FDA, updated October 30, 2026
Generic name: hydroxychloroquine
Used for: Rheumatoid arthritis · Lupus (systemic and discoid) · Malaria · Preventing malaria · 3 more
Lowest without a membership
$12.22 for 30 tablets delivered ($6.97 plus $5.25 shipping)
Generic hydroxychloroquine 200 mg from Cost Plus Drugs, by mail
With a membership $8.90 for 30 tablets from Amazon Pharmacy, by mail ($139 a year).
Open Amazon PharmacyA regular generic has the same active ingredient as Plaquenil, and the FDA requires it to work the same way.
Details for each option
Optum Perks, Optum’s free discount coupon, lists these prices for Plaquenil without insurance. Show the coupon from its page at the pharmacy; it can’t be used with insurance.
From Optum Perks, read November 2, 2026, with no location set. Its page opens on this dose; other doses and pharmacies near you are priced there too. With insurance, check your co-pay first: it may be lower.
An authorized generic of Plaquenil was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (hydroxychloroquine sulfate) is available.
Source: FDA, updated October 30, 2026
Pharmacies’ own cash prices for generic hydroxychloroquine, lowest first.
Pick up in storeDelivered
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
10 companies sell a generic of Plaquenil that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
Has lactose
Product page on accordhealthcare.us
200 mg White, double circle, 13 mm, marked “H11”
| Package | NDC |
|---|---|
| Bottle of 100 | 16729-485-01 |
| Bottle of 500 | 16729-485-16 |
Inactive ingredients: lactose monohydrate, starch, corn, magnesium stearate, povidone k30, polyethylene glycol 4000, polyvinyl alcohol, talc, titanium dioxide
200 mg White to off-white, capsule, 13 mm, marked “AC54”
| Package | NDC |
|---|---|
| Bottle of 100 | 69238-1544-1 |
| Bottle of 500 | 69238-1544-5 |
Inactive ingredients: croscarmellose sodium, dibasic calcium phosphate dihydrate, magnesium stearate, polyethylene glycol 3350, polyvinyl alcohol, sodium lauryl sulfate, starch, corn, talc, titanium dioxide
Has lactose
Product page on aurobindousa.com
200 mg White, round, 10 mm, marked “C”
| Package | NDC |
|---|---|
| Bottle of 100 | 59651-889-01 |
| Bottle of 500 | 59651-889-05 |
Inactive ingredients: anhydrous lactose, croscarmellose sodium, hypromellose 2910 (6 mpa.s), hypromellose 2910 (3 mpa.s), hypromellose 2910 (50 mpa.s), magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol 8000, povidone k30, sodium lauryl sulfate, titanium dioxide, triacetin
Has lactose
200 mg White to off white, oval, 13 mm, marked “CE / 173”
| Package | NDC |
|---|---|
| Bottle of 90 | 62135-752-90 |
Inactive ingredients: silicon dioxide, crospovidone, hypromellose, lactose monohydrate, silodrate, magnesium stearate, polyethylene glycol, povidone, talc, titanium dioxide
Has lactose · Made by Appco Pharma
200 mg White to off-white, oval, 12 mm, marked “AC / 384”
| Package | NDC |
|---|---|
| Bottle of 100 | 43598-721-01 |
| Bottle of 500 | 43598-721-05 |
Inactive ingredients: crospovidone, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, polyvinyl alcohol, starch, corn, talc, titanium dioxide
Product page on unichemusa.com
200 mg White, capsule, 14 mm, marked “HCQS”
| Package | NDC |
|---|---|
| Bottle of 10 | 83980-001-97 |
| Bottle of 100 | 83980-001-01 |
| Bottle of 500 | 83980-001-05 |
| Bottle of 1000 | 83980-001-10 |
Inactive ingredients: anhydrous dibasic calcium phosphate, hypromellose, magnesium stearate, polyethylene glycol 3350, polysorbate 80, silicon dioxide, starch, corn, talc, titanium dioxide
Made by Zydus Lifesciences
Product page on northstarrxllc.com
200 mg WHITE TO OFF-WHITE, capsule, 13 mm, marked “ZC38”
| Package | NDC |
|---|---|
| Bottle of 100 | 16714-110-01 |
| Bottle of 500 | 16714-110-02 |
Inactive ingredients: dibasic calcium phosphate dihydrate, magnesium stearate, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, starch, corn
Has lactose · Made by Laurus Labs
200 mg White to Off White, capsule, 13 mm, marked “J2”
| Package | NDC |
|---|---|
| Bottle of 60 | 16571-112-06 |
| Bottle of 100 | 16571-112-01 |
| Bottle of 500 | 16571-112-50 |
| Bottle of 1000 | 16571-112-10 |
Inactive ingredients: magnesium stearate, polyethylene glycol 8000, povidone, lactose monohydrate, starch, corn, polyvinyl alcohol, talc, titanium dioxide
Being phased out; sold until November 2026
200 mg White, oval, 13 mm, marked “TV / 2401”
| Package | NDC |
|---|---|
| Bottle of 100 | 0093-2401-01 |
Inactive ingredients: calcium phosphate, dibasic, dihydrate, hypromellose 2910 (3 mpa.s), hypromellose 2910 (6 mpa.s), hypromellose 2910 (50 mpa.s), magnesium stearate, polydextrose, polyethylene glycol 8000, starch, corn, titanium dioxide, triacetin
200 mg WHITE TO OFF-WHITE, oval, 13 mm, marked “ZC38”
| Package | NDC |
|---|---|
| Bottle of 100 | 68382-096-01 |
| Carton of 100 | 68382-096-77 |
| Bottle of 500 | 68382-096-05 |
Inactive ingredients: dibasic calcium phosphate dihydrate, magnesium stearate, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, starch, corn
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
PLAQUENIL is an antimalarial and antirheumatic indicated for the: • Treatment of uncomplicated malaria due to Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale, and Plasmodium vivax in adult and pediatric patients. • Prophylaxis of malaria in geographic areas where chloroquine resistance is not reported in adult and pediatric patients. • Treatment of rheumatoid arthritis in adults. • Treatment of systemic lupus erythematosus in adults. • Treatment of chronic discoid lupus erythematosus in adults. Limitations of Use: PLAQUENIL is not recommended for the: • Treatment of complicated malaria. • Treatment of chloroquine or hydroxychloroquine-resistant strains of Plasmodium species. • Treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified. • Prophylaxis of malaria in geographic areas where chloroquine resistance occurs. • Prevention of relapses of P. vivax or P. ovale because it is not active against the hypnozoite liver stage forms of these parasites. For radical cure of P. vivax and P. ovale infections, concomitant therapy with an 8-aminoquinoline drug is necessary.
Source: the FDA label for Plaquenil (Advanz Pharma (US) Corp.), April 9, 2026. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/plaquenil/