Premarin vs. its authorized generic and generics

Strength How many

How to pay the least

From

$150 for 30 tablets, any strength

Generic conjugated estrogens from Rx Outreach, by mail

Make a free account on rxoutreach.org. Ask your prescriber to send the prescription there, or Rx Outreach can transfer it.Open Rx Outreach
Order generic conjugated estrogens. It comes by mail.

Has to be Premarin? TrumpRx.gov lists it for $99 for 30 tablets without insurance. Get the free coupon on TrumpRx’s page and show it at the pharmacy.

See it on TrumpRx.gov

A regular generic has the same active ingredient as Premarin, and the FDA requires it to work the same way.

Compare every option

Brand namePremarin

Authorized genericconjugated estrogens

Regular genericconjugated estrogens

What you’d pay

From$99for 30 tablets at TrumpRx.gov

Cash priceAsk the pharmacyUsually among the lowest

From$150for 30 tablets at Rx Outreach

Same as Premarin?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

Premarin’s maker has a savings card that lowers what you pay at the pharmacy.

Pfizer MHT Co-pay Savings Card

Savings card from Pfizer

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $25 a prescription

The card takes up to $120 a fill off your co-pay.

Or call 1-888-966-4584.

In the maker’s words

“may pay as little as $25 per prescription filled, with the following maximum savings amounts per prescription filled:”

From the maker’s offer on pfizermenopause.pfizerpro.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Brand nameTrumpRx.gov price

TrumpRx.gov, the federal government’s drug price site, lists Premarin at a price its maker agreed to, for people paying without insurance.

TrumpRx.gov $99for 30 tabletsSame price for 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg and 1.25 mgGet the free coupon on TrumpRx’s page and show it at the pharmacy.

From TrumpRx.gov, read October 28, 2026. Its page opens on this price; other strengths and amounts are priced there too. With insurance, check your co-pay first: it may be lower.

Authorized genericThe NDC to ask for

The same medicine as Premarin, without the brand name. Give the pharmacy its NDC to get it.

conjugated estrogens

Sold by

Prasco Laboratories

Your strength

NDC to ask for

0.3 mgtablet
- 66993-295-0211-digit: 66993-0295-02100 tablets per bottle
0.45 mgtablet
- 66993-296-0211-digit: 66993-0296-02100 tablets per bottle
0.625 mgtablet
- 66993-297-0211-digit: 66993-0297-02100 tablets per bottle
0.9 mgtablet
- 66993-298-0211-digit: 66993-0298-02100 tablets per bottle
1.25 mgtablet
- 66993-299-0211-digit: 66993-0299-02100 tablets per bottle

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Premarin, can you tell me what I’d pay for the brand, for the authorized generic from Prasco Laboratories, and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

0.3 mg tablet

Same active and inactive ingredients as Premarin.

Authorized generic package label from Prasco Laboratories — Authorized genericPrasco Laboratories

See the ingredients

Active: estrogens, conjugated 0.3 mg

Inactive, on both labels:

Carnauba wax
D&C Yellow No. 10
FD&C Blue No. 2
Hydroxypropyl cellulose
Hypromellose 2208
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polyethylene glycol 400
Polysorbate 80
Powdered cellulose
Sucrose
Titanium dioxide
Tribasic calcium phosphate

0.45 mg tablet

Same active and inactive ingredients as Premarin.

See the ingredients

Active: estrogens, conjugated 0.45 mg

Inactive, on both labels:

Carnauba wax
FD&C Blue No. 2
Hydroxypropyl cellulose
Hypromellose 2208
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polyethylene glycol 400
Polysorbate 80
Powdered cellulose
Sucrose
Titanium dioxide
Tribasic calcium phosphate

0.625 mg tablet

Same active and inactive ingredients as Premarin.

See the ingredients

Active: estrogens, conjugated 0.625 mg

Inactive, on both labels:

Carnauba wax
FD&C Blue No. 2
FD&C Red No. 40
Hydroxypropyl cellulose
Hypromellose 2208
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polyethylene glycol 400
Powdered cellulose
Sucrose
Titanium dioxide
Tribasic calcium phosphate

0.9 mg tablet

Same active and inactive ingredients as Premarin.

See the ingredients

Active: estrogens, conjugated 0.9 mg

Inactive, on both labels:

Ammonia
Carnauba wax
D&C Red No. 30
D&C Red No. 7
Hydroxypropyl cellulose
Hypromellose 2208
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polyethylene glycol 400
Polysorbate 80
Powdered cellulose
Sucrose
Titanium dioxide
Tribasic calcium phosphate

1.25 mg tablet

Same active and inactive ingredients as Premarin.

See the ingredients

Active: estrogens, conjugated 1.25 mg

Inactive, on both labels:

Carnauba wax
D&C Yellow No. 10
FD&C Yellow No. 6
Ferrosoferric oxide
Hydroxypropyl cellulose
Hypromellose 2208
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Hypromellose 2910
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polydextrose
Polyethylene glycol 400
Polyethylene glycol 8000
Powdered cellulose
Sucrose
Titanium dioxide
Triacetin
Tribasic calcium phosphate

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic conjugated estrogens, lowest first.

Delivered

Delivered: Rx Outreach $150for 30 tablets0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mgFree delivery
Delivered: Amazon Pharmacy $180.81for 30 tablets0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mgPrime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericWho makes it

One company sells a generic of Premarin that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Ingenus Pharmaceuticals0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg

Has lactose · Has dyes: D&C Yellow No. 10 aluminum lake, FD&C Blue No. 2 aluminum lake, FD&C Blue No. 1 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Yellow No. 6 aluminum lake · Made by Novast Laboratories

How it looks, what’s in it, NDCs

0.3 mg GREEN, oval, 12 mm, marked “CT1 / NL”

Package NDC
Bottle of 100 50742-387-01
Bottle of 1000 50742-387-10

0.45 mg BLUE, oval, 12 mm, marked “CT2 / NL”

Package NDC
Bottle of 100 50742-388-01
Bottle of 1000 50742-388-10

0.625 mg PEACH, oval, 12 mm, marked “CT3 / NL”

Package NDC
Bottle of 100 50742-389-01
Bottle of 1000 50742-389-10

0.9 mg WHITE, oval, 12 mm, marked “CT4 / NL”

Package NDC
Bottle of 100 50742-390-01
Bottle of 1000 50742-390-10

1.25 mg YELLOW, oval, 12 mm, marked “CT5 / NL”

Package NDC
Bottle of 100 50742-391-01
Bottle of 1000 50742-391-10

Inactive ingredients: hypromelloses, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol 400, povidone, sodium acetate anhydrous, titanium dioxide, D&C Yellow No. 10 aluminum lake, FD&C Blue No. 2 aluminum lake, FD&C Blue No. 1 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Yellow No. 6 aluminum lake
FDA label

Package	NDC
Bottle of 100	50742-387-01
Bottle of 1000	50742-387-10

Package	NDC
Bottle of 100	50742-388-01
Bottle of 1000	50742-388-10

Package	NDC
Bottle of 100	50742-389-01
Bottle of 1000	50742-389-10

Package	NDC
Bottle of 100	50742-390-01
Bottle of 1000	50742-390-10

Package	NDC
Bottle of 100	50742-391-01
Bottle of 1000	50742-391-10

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

What the FDA label says

PREMARIN is a mixture of estrogens indicated for:

Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause
Treatment of Moderate to Severe Vulvar and Vaginal Atrophy due to Menopause
Treatment of Hypoestrogenism due to Hypogonadism, Castration or Primary Ovarian Failure
Treatment of Breast Cancer (for Palliation Only) in Appropriately Selected Women and Men with Metastatic Disease
Treatment of Advanced Androgen-Dependent Carcinoma of the Prostate (for Palliation Only)
Prevention of Postmenopausal Osteoporosis

Source: the FDA label for Premarin (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.), June 4, 2026. Full label on DailyMed

Good to know

It may look different from Premarin (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/premarin/