Generic name: conjugated estrogens and medroxyprogesterone
Used for: Hot flashes from menopause · Vaginal dryness from menopause (vaginal atrophy) · Preventing osteoporosis after menopause · 2 more
Cash price
$260+ for 30 tablets
Pharmacies pay about this for Prempro; you’d pay more.
Free from the maker, if you qualify Pfizer Patient Assistance Program. Meet the income requirements – Your annual household pre-tax income cannot exceed 300% of the Federal Poverty Level, adjusted for household size.
Or call 1-844-989-7284.
No generic is sold yet.
Details for each option
Savings card from Pfizer
The card takes up to $1,440 a year off your co-pay.
Sign up on pfizermenopause.
“Prempro up to $110 savings…”
From the maker’s offer on pfizermenopause.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.
TrumpRx.gov, the federal government’s drug price site, lists Prempro at a price its maker agreed to, for people paying without insurance.
From TrumpRx.gov, read October 28, 2026. Its page opens on this price; other strengths and amounts are priced there too. With insurance, check your co-pay first: it may be lower.
Optum Perks, Optum’s free discount coupon, lists these prices for Prempro without insurance. Show the coupon from its page at the pharmacy; it can’t be used with insurance.
From Optum Perks, read November 2, 2026, with no location set. Its page opens on this dose; other doses and pharmacies near you are priced there too. With insurance, check your co-pay first: it may be lower.
There isn’t one. An authorized generic is Prempro itself, from the same company, sold without the brand name, and usually for less. For now Prempro is the only choice; its maker’s savings card can lower what you pay.
No generic is sold yet. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.
PREMPRO/PREMPHASE is an estrogen plus progestin indicated in a woman with a uterus for:
Source: the FDA label for Prempro (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.), April 28, 2026. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/prempro/