How to pay the least
From
$16.36 for 30 tablets delivered ($11.11 plus $5.25 shipping)
Generic desvenlafaxine ER from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.
- Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
- Order generic desvenlafaxine ER. It comes by mail.
Need it today? From $20.29 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.
See the price and get the cardHas to be Pristiq? TrumpRx.gov lists it for $200.10 for 30 tablets without insurance. Get the free coupon on TrumpRx’s page and show it at the pharmacy.
See it on TrumpRx.A regular generic has the same active ingredient as Pristiq, and the FDA requires it to work the same way.
Compare every option
Details for each option
Brand nameTrumpRx.gov price
TrumpRx.gov, the federal government’s drug price site, lists Pristiq at a price its maker agreed to, for people paying without insurance.
- TrumpRx.gov $200.10for 30 tabletsSame price for 25 mg, 50 mg and 100 mgGet the free coupon on TrumpRx’s page and show it at the pharmacy.
From TrumpRx.gov, read October 28, 2026. Its page opens on this price; other strengths and amounts are priced there too. With insurance, check your co-pay first: it may be lower.
Authorized genericNot sold
There isn’t one. An authorized generic is Pristiq itself, from the same company, sold without the brand name, and usually for less. A regular generic is sold, with the same active ingredient: ask the pharmacy for its price.
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic desvenlafaxine, lowest first.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs from $11.11for 30 tablets25 mg $16.66 · 50 mg $13.21 · 100 mg $11.11Plus $5.25 shipping
- Pick up in store: Team Cuban Card $20.29for 30 tablets100 mgFree card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
- Pick up in store: Costco $28.99for 30 tablets50 mgMembers only · $65 a yearFind the nearest store
- Delivered: Costco $28.99for 30 tablets50 mgMembers only · $65 a year · Plus shipping
- Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
About these prices
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
8 companies sell a generic of Pristiq that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
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Actavis PharmaAll 3 strengths
Being phased out; sold until January 2027
How it looks, what’s in it, NDCs
25 mg Light pink, square, 9 mm, marked “A112”
Package NDC Bottle of 30 0591-4060-30 50 mg Light pink, square, 12 mm, marked “WPI / 3659”
Package NDC Bottle of 30 0591-3659-30 100 mg Reddish-orange, square, 12 mm, marked “WPI / 3660”
Package NDC Bottle of 30 0591-3660-30 Inactive ingredients: silicon dioxide, hypromellose 2208 (100 mpa.s), magnesium stearate, microcrystalline cellulose, polyethylene oxide 100000, talc, ferric oxide red, ferric oxide yellow, polyethylene glycol 3350, polyvinyl alcohol, titanium dioxide, ammonia, ferrosoferric oxide, propylene glycol, shellac
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Advagen PharmaAll 3 strengths
Has dyes: FD&C Red No. 40, FD&C Yellow No. 6 · Made by Rubicon Research
How it looks, what’s in it, NDCs
25 mg Brown, round, 10 mm, marked “UpArrowhead / A41”
Package NDC Package of 30 72888-175-30 Package of 90 72888-175-90 Package of 500 72888-175-05 Package of 1000 72888-175-00 50 mg Pink, round, 10 mm, marked “UpArrowhead / A42”
Package NDC Package of 30 72888-143-30 Package of 90 72888-143-90 Package of 500 72888-143-05 Package of 1000 72888-143-00 100 mg Beige, round, 10 mm, marked “UpArrowhead / A43”
Package NDC Package of 30 72888-144-30 Package of 90 72888-144-90 Package of 500 72888-144-05 Package of 1000 72888-144-00 Inactive ingredients: hypromellose, microcrystalline cellulose, talc, magnesium stearate, polyvinyl alcohol, polyethylene glycol, titanium dioxide, ferric oxide yellow, ferric oxide red, FD&C Red No. 40, FD&C Yellow No. 6, ferrosoferric oxide
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Breckenridge PharmaceuticalAll 3 strengths
Made by Alembic Pharmaceuticals
Product page on breckenridgepharma.com
How it looks, what’s in it, NDCs
25 mg Tan, round, 10 mm, marked “L634”
Package NDC Bottle of 30 51991-006-33 Carton of 80 51991-006-80 Bottle of 90 51991-006-90 Bottle of 100 51991-006-01 Carton of 100 51991-006-11 Bottle of 1000 51991-006-10 50 mg Light Pink, round, 10 mm, marked “L349”
Package NDC Bottle of 14 51991-311-14 Bottle of 30 51991-311-33 Carton of 80 51991-311-80 Bottle of 90 51991-311-90 Bottle of 100 51991-311-01 Carton of 100 51991-311-11 Bottle of 1000 51991-311-10 100 mg Dark Brown to Red, round, 10 mm, marked “L350”
Package NDC Bottle of 14 51991-312-14 Bottle of 30 51991-312-33 Carton of 80 51991-312-80 Bottle of 90 51991-312-90 Bottle of 100 51991-312-01 Carton of 100 51991-312-11 Bottle of 1000 51991-312-10 Inactive ingredients: hypromellose, microcrystalline cellulose, povidone k90, talc, magnesium stearate, titanium dioxide, polyethylene glycol 6000, ferric oxide red, ferric oxide yellow, ferrosoferric oxide, polyethylene glycol 8000
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Hikma PharmaceuticalsAll 3 strengths
Has dyes: FD&C Blue No. 1, FD&C Red No. 40, FD&C Yellow No. 6
How it looks, what’s in it, NDCs
25 mg Beige, round, 10 mm, marked “54 / 427”
Package NDC Bottle of 30 0054-0603-13 50 mg Peach, round, 10 mm, marked “54 / 716”
Package NDC Bottle of 30 0054-0400-13 Bottle of 90 0054-0400-22 100 mg Peach, round, 10 mm, marked “54 / 341”
Package NDC Bottle of 30 0054-0401-13 Bottle of 90 0054-0401-22 Inactive ingredients: silicon dioxide, hypromellose 2208 (100 mpa.s), magnesium stearate, microcrystalline cellulose, povidone k30, sodium stearyl fumarate, FD&C Red No. 40, FD&C Yellow No. 6, FD&C Blue No. 1, polyvinyl alcohol, polyethylene glycol 1000, talc, titanium dioxide
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Lupin PharmaceuticalsAll 3 strengths
Has a dye: FD&C Yellow No. 6
How it looks, what’s in it, NDCs
25 mg Tan, round, 9 mm, marked “LU / S67”
Package NDC Bottle of 30 68180-604-06 50 mg Light Pink, round, 10 mm, marked “LU / S61”
Package NDC Bottle of 30 68180-592-06 100 mg Reddish Orange, round, 11 mm, marked “LU / S62”
Package NDC Bottle of 30 68180-593-06 Inactive ingredients: cellulose, microcrystalline, ferric oxide red, ferrosoferric oxide, hypromellose, magnesium stearate, polyethylene glycol 3350, polyvinyl alcohol, silicon dioxide, talc, titanium dioxide, ferric oxide yellow, hypromelloses, FD&C Yellow No. 6
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Macleods Pharmaceuticals50 mg, 100 mg
Has a dye: FD&C Yellow No. 6
How it looks, what’s in it, NDCs
50 mg Pink, round, 10 mm, marked “M41”
Package NDC Bottle of 30 33342-388-07 Bottle of 90 33342-388-10 Carton of 100 33342-388-12 100 mg Reddish orange colour, round, 10 mm, marked “M42”
Package NDC Bottle of 30 33342-389-07 Bottle of 90 33342-389-10 Carton of 100 33342-389-12 Inactive ingredients: cellulose, microcrystalline, hypromelloses, silicon dioxide, talc, magnesium stearate, polyethylene glycol 400, titanium dioxide, ferric oxide red, ferric oxide yellow, FD&C Yellow No. 6
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NorthStar RxAll 3 strengths
Has dyes: FD&C Red No. 40, FD&C Yellow No. 6 · Made by Rubicon Research
Product page on northstarrxllc.com
How it looks, what’s in it, NDCs
25 mg Brown, round, 10 mm, marked “UpArrowhead / A41”
Package NDC Package of 30 72603-555-01 50 mg Pink, round, 10 mm, marked “UpArrowhead / A42”
Package NDC Package of 30 72603-556-01 Package of 90 72603-556-02 100 mg Beige, round, 10 mm, marked “UpArrowhead / A43”
Package NDC Package of 90 72603-557-01 Inactive ingredients: hypromellose, microcrystalline cellulose, talc, magnesium stearate, polyvinyl alcohol, polyethylene glycol, titanium dioxide, ferric oxide yellow, ferric oxide red, FD&C Red No. 40, FD&C Yellow No. 6, ferrosoferric oxide
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Slate Run PharmaceuticalsAll 3 strengths
Has dyes: D&C Red No. 27 aluminum lake, FD&C Blue No. 2, FD&C Yellow No. 6 · Made by Yichang Humanwell Pharmaceutical
Product page on slaterunpharma.com
How it looks, what’s in it, NDCs
25 mg LIGHT TAN, square, 9 mm, marked “YH / 137”
Package NDC Bottle of 30 70436-036-04 50 mg LIGHT-PINK, square, 9 mm, marked “YH / 50”
Package NDC Bottle of 30 70436-012-04 Bottle of 90 70436-012-06 100 mg Red, square, 9 mm, marked “YH / 100”
Package NDC Bottle of 30 70436-013-04 Bottle of 90 70436-013-06 Inactive ingredients: hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene oxide 900000, talc, silicon dioxide, ferrosoferric oxide, ferric oxide red, ferric oxide yellow, polyvinyl alcohol graft polyethylene glycol copolymer (3:1; 45000 mw), titanium dioxide, polyethylene glycol 3350, polyvinyl alcohol, FD&C Blue No. 2, FD&C Yellow No. 6, D&C Red No. 27 aluminum lake
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What to say at the pharmacy
“Before you fill my Pristiq, can you tell me what I’d pay for the brand and for a generic?”
Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.
What it’s used for
What the FDA label says
PRISTIQ is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of adults with major depressive disorder (MDD).
Source: the FDA label for Pristiq (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.), April 28, 2026. Full label on DailyMed
Good to know
- A regular generic may look different from Pristiq. The FDA requires it to work the same way.
- We didn’t find a savings card from Pristiq’s maker.
- Don’t stop or change a medicine without talking to your pharmacist or prescriber.
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/pristiq/