Brand-name prescription

Pulmozyme

dornase alfa

Compare your options

Compare	PulmozymeBrand name	Authorized genericWithout the Pulmozyme name	Regular genericdornase alfa
What pharmacies pay	$133per 2.5 mL ampule	Not sold	Not sold
Same as Pulmozyme?	The original	–	–
Ways to save	Maker’s cardas little as $30 a monthwith commercial insurance	–	–
With insurance	Your plan’s brand co-pay	–	–

No authorized generic: There isn’t one.

No regular generic: Pulmozyme is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold.

Prices are the average U.S. drugstores pay (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

The maker’s savings card

Rx Maker’s savings card Genentech

Pulmozyme Co-pay Program

With commercial insurance

as little as $30 a month

No insurance

This card needs commercial insurance. The maker doesn’t list a cash price on this page.

The card pays up to $10,000 a year.

Get it on pulmozyme.com

In the maker’s words

“The Pulmozyme Co-pay Program works to help eligible, commercially insured patients pay as little as $30 for a 30-day supply of Pulmozyme.”

From the maker’s offer on pulmozyme.com, checked September 25, 2026. What you pay depends on your plan. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Before you use a discount card

Discount cards like GoodRx take money off the pharmacy’s cash price. For a brand-name drug, that price is often still high. With commercial insurance, Pulmozyme’s own card may bring it to as little as $30 a month.

Look up the discount-card price, then compare it with this estimate. You can use a maker’s card or a discount card, but usually not both on the same fill.

What pharmacies pay

The average U.S. drugstores pay for each strength (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Strength	Pulmozyme
1 mg/mL ampulper 2.5 mL ampule	$133

Good to know

There’s no authorized generic of Pulmozyme.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.