Generic name: bismuth subcitrate, metronidazole, and tetracycline
Used for: H. pylori infection and ulcers
Ask for the cash price
Generic bismuth subcitrate, metronidazole, and tetracycline
No pharmacy we check posts a price for bismuth subcitrate, metronidazole, and tetracycline 140 mg / 125 mg / 125 mg, 30 capsules. Pharmacies pay about $90 for 30 capsules; cash prices are higher. Ask two or three.
A regular generic has the same active ingredient as Pylera, and the FDA requires it to work the same way.
Details for each option
We didn’t find a savings card or cash price from Pylera’s maker. Ask the pharmacy for Pylera’s cash price. With insurance, ask what your plan charges.
The same medicine as Pylera, without the brand name. Give the pharmacy its NDC to get it.
bismuth subcitrate, metronidazole, and tetracycline
Source: FDA, updated October 30, 2026
“Before you fill my Pylera, can you tell me what I’d pay for the brand, for the authorized generic from H2-Pharma (NDC 61269-386-12), and for a regular generic?”
Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.
Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).
Same active and inactive ingredients as Pylera.
Active: bismuth subcitrate potassium 140 mg · metronidazole 125 mg · tetracycline hydrochloride 125 mg
Inactive, on both labels:
2 companies sell a generic of Pylera that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
Has lactose
140 mg / 125 mg / 125 mg Opaque body and a white opaque cap, capsule, 22 mm, marked “ING283”
| Package | NDC |
|---|---|
| Carton of 120 | 50742-283-13 |
Inactive ingredients: magnesium stearate, lactose monohydrate, talc, gelatin, titanium dioxide, ammonia, ferrosoferric oxide, propylene glycol, shellac
Has dyes: FD&C Blue No. 2, FD&C Red No. 40 · Made by PH Health
140 mg / 125 mg / 125 mg White opaque, capsule, 21 mm, marked “PAR / 440”
| Package | NDC |
|---|---|
| Carton of 120 | 49884-151-54 |
Inactive ingredients: silicon dioxide, FD&C Blue No. 2, FD&C Red No. 40, gelatin, lecithin, soybean, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, povidone, shellac, sodium hydroxide, sodium lauryl sulfate, sodium stearyl fumarate, talc, titanium dioxide, xanthan gum, propylene glycol, starch, corn
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
PYLERA is a combination of metronidazole, a nitroimidazole antimicrobial, tetracycline,- a tetracycline class antimicrobial and bismuth subcitrate potassium, indicated for use, in combination with omeprazole, for the treatment of patients with Helicobacter pylori infection and duodenal ulcer disease (active or history of within the past 5 years) to eradicate H. pylori.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of PYLERA and other antibacterial drugs, PYLERA should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Source: the FDA label for Pylera (H2-Pharma, LLC), June 29, 2026. Full label on DailyMed
Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/pylera/