Rybrevant Faspro

Generic name: amivantamab and hyaluronidase-lpuj (human recombinant)

Used for: Non-small cell lung cancer with an EGFR mutation

How do you pay?

How to pay the least

Ask for the cash price

Rybrevant Faspro

Rybrevant Faspro is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold.

  1. Ask your pharmacy for Rybrevant Faspro’s cash price, and one or two other pharmacies too.
  2. Rybrevant Faspro’s savings card works only with insurance from a job or one you bought.

Free from the maker, if you qualify Johnson & Johnson Patient Assistance Program. Patients’ income must be equal to or less than 300% of Federal Poverty Level (FPL). Or call 1-833-742-0791.

See if you qualify 

Compare every option

Question
Brand nameRybrevant Faspro
Authorized genericamivantamab and hyaluronidase-lpuj (human recombinant)
Regular genericamivantamab and hyaluronidase-lpuj (human recombinant)
What you’d pay
Cash priceAsk the pharmacy
Not soldThere isn’t one
Not soldAsk the pharmacy
Same as Rybrevant Faspro?
The original
–
–

Brand nameThe maker’s card

J&J withMe Savings Program

Savings card from Johnson & Johnson (Janssen)

No insuranceNeeds insuranceNo cash price listed.
Insurance $0 a dose

Sign up on jnjwithme.com 

Or call 1-833-565-9631.

In the maker’s words

“Eligible patients pay $0 for each dose.”

From the maker’s offer on jnjwithme.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s card above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Rybrevant Faspro itself, from the same company, sold without the brand name, and usually for less. For now Rybrevant Faspro is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

Rybrevant Faspro is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

What the FDA label says

RYBREVANT FASPRO is a combination of amivantamab, a bispecific EGF receptor-directed and MET receptor-directed antibody, and hyaluronidase, an endoglycosidase indicated:

  • in combination with lazertinib for the first-line treatment of adult patients with locally advanced or metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R substitution mutations, as detected by an FDA-approved test.
  • in combination with carboplatin and pemetrexed for the treatment of adult patients with locally advanced or metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R substitution mutations, whose disease has progressed on or after treatment with an EGFR tyrosine kinase inhibitor.
  • in combination with carboplatin and pemetrexed for the first-line treatment of adult patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, as detected by an FDA-approved test.
  • as a single agent for the treatment of adult patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy.

Source: the FDA label for Rybrevant Faspro (Janssen Biotech, Inc.), June 17, 2026. Full label on DailyMed 

Good to know

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/rybrevant-faspro/