Ryplazim savings card: up to $20,000 off a year with commercial insurance

Ryplazim is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

How to pay the least

Given by your care team

Billed by the clinic

Ryplazim is given by a doctor or nurse, not picked up at a pharmacy.

Ask your care team or your plan what you’d pay before your visit.

Compare every option

Brand nameRyplazim

Authorized genericplasminogen

Regular genericplasminogen

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldAsk the pharmacy

Same as Ryplazim?

The original

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Brand nameThe maker’s card

RYPLAZIM Copay Assistance Program

Savings card from Kedrion Biopharma

No insuranceNeeds insuranceNo cash price listed.

Insurance · up to $20,000 off a year

The card takes up to $20,000 a year off your co-pay.

Or call 1-888-262-8040.

In the maker’s words

“Eligible patients can receive up to $20,000 over 12 months to cover the deductible, copay, and/or coinsurance for RYPLAZIM.”

From the maker’s offer on ryplazim.medmonk.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericNot sold

There isn’t one. An authorized generic is Ryplazim itself, from the same company, sold without the brand name, and usually for less. For now Ryplazim is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

Ryplazim is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Plasminogen deficiency type 1

What the FDA label says

RYPLAZIM® (plasminogen, human-tvmh) is plasma-derived human plasminogen indicated for the treatment of patients with plasminogen deficiency type 1 (hypoplasminogenemia).

Source: the FDA label for Ryplazim (Kedrion Biopharma, Inc.), September 21, 2026. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to the clinic’s billing office.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/ryplazim/