Brand-name prescription

Ryplazim

plasminogen

Compare your options

Ryplazim is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

Compare	RyplazimBrand name	Authorized genericWithout the Ryplazim name	Regular genericplasminogen
What pharmacies pay	Price not listed	Not sold	Not sold
Same as Ryplazim?	The original	–	–
Ways to save	Maker’s cardup to $20,000 off a yearwith commercial insurance	–	–
With insurance	Your plan’s brand co-pay	–	–

No authorized generic: There isn’t one.

No regular generic: Ryplazim is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold.

Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

The maker’s savings card

Rx Maker’s savings card Kedrion Biopharma

RYPLAZIM Copay Assistance Program

With commercial insurance

up to $20,000 off a year

No insurance

This card needs commercial insurance. The maker doesn’t list a cash price on this page.

The card pays up to $20,000 a year.

Get it on ryplazim.medmonk.com

In the maker’s words

“Eligible patients can receive up to $20,000 over 12 months to cover the deductible, copay, and/or coinsurance for RYPLAZIM.”

From the maker’s offer on ryplazim.medmonk.com, checked September 25, 2026. What you pay depends on your plan. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Good to know

There’s no authorized generic of Ryplazim.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to the clinic’s billing office.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.