Safyral vs. its authorized generic and generics

How to pay the least

Ask for the cash price

Generic drospirenone, ethinyl estradiol, and levomefolate

No pharmacy we check posts a price for it.

Ask your pharmacy for the cash price of generic drospirenone, ethinyl estradiol, and levomefolate.Find pharmacies near you
Ask one or two other pharmacies too. Cash prices for the same generic can differ a lot from store to store.

A regular generic has the same active ingredient as Safyral, and the FDA requires it to work the same way.

Compare every option

Brand nameSafyral

Authorized genericdrospirenone, ethinyl estradiol, and levomefolate

Regular genericdrospirenone, ethinyl estradiol, and levomefolate

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Cash priceAsk the pharmacyOften less than Safyral

Cash priceAsk the pharmacyUsually the lowest

Same as Safyral?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Safyral’s maker. Ask the pharmacy for Safyral’s cash price. With insurance, ask what your plan charges.

Authorized genericThe NDC to ask for

The same medicine as Safyral, without the brand name. Give the pharmacy its NDC to get it.

drospirenone, ethinyl estradiol, and levomefolate

Sold by

SandozMade for Bayer HealthCare Pharmaceuticals, the company behind Safyral

NDC to ask for

3 mg / 0.03 mg / 0.451 mgkit
- 0781-4103-1511-digit: 00781-4103-153 blister packs per package

Source: FDA, updated October 30, 2026

What to say at the pharmacy

“Before you fill my Safyral, can you tell me what I’d pay for the brand, for the authorized generic from Sandoz (NDC 0781-4103-15), and for a regular generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

Same active and inactive ingredients as Safyral.

Authorized generic package label from Sandoz — Authorized genericSandoz

See the ingredients

Active: drospirenone 3 mg · ethinyl estradiol 0.03 mg · levomefolate calcium 0.451 mg · levomefolate calcium 0.451 mg

Inactive, on both labels:

Betadex
Croscarmellose sodium
Ferric oxide red
Ferric oxide yellow
Hydroxypropyl cellulose
Hypromellose
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Polyethylene glycol
Talc
Titanium dioxide

Regular genericWho makes it

One company sells a generic of Safyral that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

Lupin Pharmaceuticals

Has lactose · Sold as Tydemy

How it looks, what’s in it, NDCs

Package NDC
Carton of 3 68180-904-73

Inactive ingredients: ascorbic acid, croscarmellose sodium, ferric oxide red, ferric oxide yellow, hydroxypropyl cellulose, low substituted, hypromelloses, lactose monohydrate, magnesium stearate, polyethylene glycol, starch, corn, talc, titanium dioxide
FDA label

Package	NDC
Carton of 3	68180-904-73

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What it’s used for

Preventing pregnancy (birth control)
Raising folate (a B vitamin) levels

What the FDA label says

Safyral is a combination of drospirenone, a progestin and ethinyl estradiol, an estrogen containing a folate, indicated for use by females of reproductive potential to:

Prevent pregnancy.
Raise folate levels in females of reproductive potential who choose to use an oral contraceptive for contraception.

Source: the FDA label for Safyral (Bayer HealthCare Pharmaceuticals Inc.), March 4, 2026. Full label on DailyMed

Good to know

It may look different from Safyral (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
If your pharmacy doesn’t stock it, they can often order it within a day or two.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/safyral/