An authorized generic of Samsca was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (tolvaptan) is available.
Source: FDA, updated October 30, 2026
How to pay the least
From
$165.50 for 30 tablets delivered ($160.25 plus $5.25 shipping)
Generic tolvaptan from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.
- Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
- Order generic tolvaptan. It comes by mail.
Need it today? From $203.54 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.
See the price and get the cardA regular generic has the same active ingredient as Samsca, and the FDA requires it to work the same way.
Compare every option
Question
Brand nameSamsca
Authorized generictolvaptan
Regular generictolvaptan
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Not soldNo longer sold
Same as Samsca?
The original
–
Same active ingredientFillers and dyes can differ
Details for each option
Details for
Brand nameNo maker’s card
We didn’t find a savings card or cash price from Samsca’s maker. Ask the pharmacy for Samsca’s cash price. With insurance, ask what your plan charges.
Authorized genericNot sold now
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic tolvaptan, lowest first.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs from $160.25for 30 tablets15 mg $160.25 · 30 mg $284.45Plus $5.25 shipping
- Pick up in store: Team Cuban Card from $203.54for 30 tablets15 mg $203.54 · 30 mg $353.38Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
About these prices
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
6 companies sell a generic of Samsca that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
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ApotexAll 2 strengths
Packages and NDCs
15 mg
Package NDC Carton of 10 60505-4317-0 Bottle of 30 60505-4317-3 30 mg
Package NDC Carton of 10 60505-4318-0 -
Ascend LaboratoriesAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2 · Made by Alkem Laboratories
How it looks, what’s in it, NDCs
15 mg Light blue to blue, round, 7 mm, marked “TOL / 15”
Package NDC Bottle of 10 67877-635-02 Carton of 10 67877-635-33 Bottle of 100 67877-635-01 30 mg Light blue to blue, round, 8 mm, marked “TOL / 30”
Package NDC Bottle of 10 67877-636-02 Carton of 10 67877-636-33 Bottle of 100 67877-636-01 Inactive ingredients: croscarmellose sodium, hypromellose 2910 (5 mpa.s), lactose monohydrate, magnesium stearate, starch, corn, microcrystalline cellulose, FD&C Blue No. 2
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Camber PharmaceuticalsAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2 · Made by Hetero Labs
Product page on camberpharma.com
How it looks, what’s in it, NDCs
15 mg Off white, triangle, 6 mm, marked “H / T9”
Package NDC Carton of 10 31722-868-03 Carton of 10 31722-868-04 Carton of 100 31722-868-01 Carton of 100 31722-868-02 30 mg Blue, round, 8 mm, marked “H / T10”
Package NDC Carton of 10 31722-869-03 Carton of 10 31722-869-04 Carton of 100 31722-869-01 Carton of 100 31722-869-02 Inactive ingredients: starch, corn, croscarmellose sodium, magnesium stearate, methyl alcohol, methylene chloride, microcrystalline cellulose 102, povidone k30, lactose monohydrate, FD&C Blue No. 2
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NorthStar RxAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2 aluminum lake · Made by MSN Laboratories
Product page on northstarrxllc.com
How it looks, what’s in it, NDCs
15 mg Blue, triangle, 7 mm, marked “MT / 7”
Package NDC Carton of 10 72603-932-01 30 mg Blue, round, 8 mm, marked “MT / 8”
Package NDC Carton of 10 72603-933-01 Inactive ingredients: starch, corn, croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose 102, FD&C Blue No. 2 aluminum lake
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Novadoz PharmaceuticalsAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2 aluminum lake · Made by MSN Laboratories
Product page on novadozpharma.com
How it looks, what’s in it, NDCs
15 mg Blue, triangle, 7 mm, marked “MT / 7”
Package NDC Carton of 10 72205-130-11 30 mg Blue, round, 8 mm, marked “MT / 8”
Package NDC Carton of 10 72205-131-11 Inactive ingredients: starch, corn, croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose 102, FD&C Blue No. 2 aluminum lake
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Par HealthAll 2 strengths
Has lactose · Has a dye: FD&C Blue No. 2 · Made by PH Health
How it looks, what’s in it, NDCs
15 mg Blue, triangle, 7 mm, marked “E / 500”
Package NDC Carton of 10 49884-768-54 30 mg Blue, round, 8 mm, marked “E / 501”
Package NDC Carton of 10 49884-770-54 Inactive ingredients: starch, corn, FD&C Blue No. 2, hydroxypropyl cellulose, lactose monohydrate, hydroxypropyl cellulose, low substituted, magnesium stearate, microcrystalline cellulose
The FDA doesn’t rate Lupin Pharmaceuticals and Teva Pharmaceuticals’s versions of tolvaptan a substitute for Samsca, so a pharmacy can’t swap them in without your prescriber’s OK.
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What it’s used for
What the FDA label says
SAMSCA is a selective vasopressin V2-receptor antagonist indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia [serum sodium <125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction], including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
Limitations of Use:
- Patients requiring intervention to raise serum sodium urgently to prevent or to treat serious neurological symptoms should not be treated with SAMSCA
- It has not been established that SAMSCA provides a symptomatic benefit to patients
Source: the FDA label for Samsca (Otsuka America Pharmaceutical, Inc.), May 7, 2026. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/samsca/