How do you pay?

How to pay the least

Ask for the cash price

Symdeko

We didn’t find one.

  1. Ask your pharmacy for Symdeko’s cash price, and one or two other pharmacies too.

Compare every option

Question
Brand nameSymdeko
Authorized generictezacaftor and ivacaftor
Regular generictezacaftor and ivacaftor
What you’d pay
Cash priceAsk the pharmacy
Not soldThere isn’t one
Not soldNone found
Same as Symdeko?
The original
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Brand nameNo maker’s card

We didn’t find a savings card or cash price from Symdeko’s maker. Ask the pharmacy for Symdeko’s cash price. With insurance, ask what your plan charges.

Authorized genericNot sold

There isn’t one. An authorized generic is Symdeko itself, from the same company, sold without the brand name, and usually for less. For now Symdeko is the only choice; ask the pharmacy for its cash price, or your plan what it charges.

Regular genericNot sold

We didn’t find one. Generics usually come once the brand’s patents and exclusivity end. Until then, ask the pharmacy for Symdeko’s cash price, or your plan what it charges.

What it’s used for

What the FDA label says

SYMDEKO is a combination of tezacaftor and ivacaftor, indicated for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who are homozygous for the F508del mutation or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to tezacaftor/ivacaftor based on in vitro data and/or clinical evidence.

If the patient's genotype is unknown, an FDA-cleared CF mutation test should be used to detect the presence of a CFTR mutation followed by verification with bi-directional sequencing when recommended by the mutation test instructions for use.

Source: the FDA label for Symdeko (Vertex Pharmaceuticals Incorporated), August 21, 2026. Full label on DailyMed 

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