An authorized generic of Syprine was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (trientine hydrochloride) is available.
Source: FDA, updated October 30, 2026
How to pay the least
Lowest price
$80.80 for 30 capsules delivered ($75.55 plus $5.25 shipping)
Generic trientine 250 mg from Cost Plus Drugs, by mail
- Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
- Order generic trientine 250 mg. It comes by mail.
A regular generic has the same active ingredient as Syprine, and the FDA requires it to work the same way.
Compare every option
Question
Brand nameSyprine
Authorized generictrientine
Regular generictrientine
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Not soldNo longer sold
Same as Syprine?
The original
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Same active ingredientFillers and dyes can differ
Details for each option
Details for
Brand nameNo maker’s card
We didn’t find a savings card or cash price from Syprine’s maker. Ask the pharmacy for Syprine’s cash price. With insurance, ask what your plan charges.
Authorized genericNot sold now
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic trientine, lowest first.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs $75.55for 30 capsules250 mgPlus $5.25 shipping
- Pick up in store: Costco $171.92for 30 capsules250 mgMembers only · $65 a yearFind the nearest store
- Delivered: Costco $171.92for 30 capsules250 mgMembers only · $65 a year · Plus shipping
- Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
About these prices
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
4 companies sell a generic of Syprine that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
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Camber Pharmaceuticals250 mg
Has dyes: D&C Red No. 28, FD&C Blue No. 1 · Made by Hetero Labs
Product page on camberpharma.com
How it looks, what’s in it, NDCs
250 mg Opaque, capsule, 20 mm, marked “H / T4”
Package NDC Carton of 100 31722-683-01 Inactive ingredients: stearic acid, D&C Red No. 28, FD&C Blue No. 1, gelatin, titanium dioxide, ferrosoferric oxide, potassium hydroxide, propylene glycol, shellac, ammonia
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Dr. Reddy’s Laboratories250 mg
How it looks, what’s in it, NDCs
250 mg Yellow opaque, capsule, 19 mm, marked “RDY / 459”
Package NDC Bottle of 100 43598-459-01 Inactive ingredients: silicon dioxide, ferric oxide yellow, gelatin, magnesium stearate, polyethylene glycol, titanium dioxide, ferrosoferric oxide, potassium hydroxide, propylene glycol, shellac
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Novadoz Pharmaceuticals250 mg
Made by MSN Laboratories
Product page on novadozpharma.com
How it looks, what’s in it, NDCs
250 mg Light brown, capsule, 19 mm, marked “250 / TRN”
Package NDC Carton of 100 72205-008-91 Inactive ingredients: gelatin, stearic acid, titanium dioxide, ferric oxide red, ferric oxide yellow, shellac, propylene glycol, potassium hydroxide, ferrosoferric oxide
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Rising Pharma Holdings250 mg
How it looks, what’s in it, NDCs
250 mg Brown opaque, capsule, 19 mm, marked “C27 / 250mg”
Package NDC Bottle of 100 16571-810-01 Inactive ingredients: gelatin, ferric oxide red, ferric oxide yellow, ferrosoferric oxide, potassium hydroxide, propylene glycol, shellac, stearic acid, titanium dioxide
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What it’s used for
What the FDA label says
Syprine is indicated in the treatment of patients with Wilson’s disease who are intolerant of penicillamine. Clinical experience with Syprine is limited and alternate dosing regimens have not been well-characterized; all endpoints in determining an individual patient’s dose have not been well defined. Syprine and penicillamine cannot be considered interchangeable. Syprine should be used when continued treatment with penicillamine is no longer possible because of intolerable or life endangering side effects.
Unlike penicillamine, Syprine is not recommended in cystinuria or rheumatoid arthritis. The absence of a sulfhydryl moiety renders it incapable of binding cystine and, therefore, it is of no use in cystinuria. In 15 patients with rheumatoid arthritis, Syprine was reported not to be effective in improving any clinical or biochemical parameter after 12 weeks of treatment.
Syprine is not indicated for treatment of biliary cirrhosis.
Source: the FDA label for Syprine (Bausch Health US LLC), September 1, 2020. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/syprine/