Thiola EC vs. its authorized generic and generics

Strength How many

How to pay the least

From

$253.54 for 30 tablets delivered ($248.29 plus $5.25 shipping)

Generic tiopronin EC from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.

Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
Order generic tiopronin EC. It comes by mail.

A regular generic has the same active ingredient as Thiola EC, and the FDA requires it to work the same way.

Compare every option

Brand nameThiola EC

Authorized generictiopronin

Regular generictiopronin

What you’d pay

Cash priceAsk the pharmacyUsually the highest price

Cash priceAsk the pharmacyOften less than Thiola EC

From$253.54for 30 tablets at Cost Plus Drugs, with shipping

Same as Thiola EC?

The original

Same medicine

Same active ingredientFillers and dyes can differ

Brand nameThe maker’s card

Thiola EC’s maker has a savings card that lowers what you pay at the pharmacy.

THIOLA/THIOLA EC Total Care HUB

Savings card from Travere Therapeutics (THIOLA and THIOLA EC are trademarks of Mission Pharmacal Company)

No insuranceNeeds insuranceNo cash price listed.

Insurance $0 a fill

Or call 1-844-484-4652.

In the maker’s words

“$0 copay for eligible, commercially insured patients, reimbursement support, and information on patient assistance programs are available for other insurance carriers.”

From the maker’s offer on thiolaechcp.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericThe NDC to ask for

The same medicine as Thiola EC, without the brand name. Give the pharmacy its NDC to get it.

tiopronin

Sold by

BioComp Pharma

How to get it

You can’t get this at a regular pharmacy. The maker only ships it through its MyCare Solutions program: your doctor starts the enrollment, and the program’s pharmacy sends it to you.

How to enroll in MyCare Solutions

Your strength

NDC to ask for

100 mgdelayed-release tablet
- 44523-054-0111-digit: 44523-0054-01300 tablets per bottle
300 mgdelayed-release tablet
- 44523-055-0111-digit: 44523-0055-0190 tablets per bottle

Source: FDA, updated October 30, 2026

What to ask your doctor

“Can you enroll me in MyCare Solutions for tiopronin delayed-release tablets, the authorized generic of Thiola EC?”

Brand and authorized generic labels

Official labels and ingredient lists from DailyMed (U.S. National Library of Medicine).

100 mg delayed-release tablet

Same active and inactive ingredients as Thiola EC.

Thiola EC package label — BrandThiola EC

Authorized generic package label from BioComp Pharma — Authorized genericBioComp Pharma

See the ingredients

Active: tiopronin 100 mg

Inactive, on both labels:

Low substituted hydroxypropyl cellulose
Hydroxypropyl cellulose
Hypromellose
Lactose monohydrate
Magnesium stearate
Methacrylic acid-ethyl acrylate copolymer type A
Talc
Triethyl citrate

300 mg delayed-release tablet

Same active and inactive ingredients as Thiola EC.

See the ingredients

Active: tiopronin 300 mg

Inactive, on both labels:

Low substituted hydroxypropyl cellulose
Hydroxypropyl cellulose
Hypromellose
Lactose monohydrate
Magnesium stearate
Methacrylic acid-ethyl acrylate copolymer type A
Talc
Triethyl citrate

Regular genericWhere to buy it

Pharmacies’ own cash prices for generic tiopronin, lowest first.

Delivered

Delivered: Cost Plus Drugs from $248.29for 30 tablets100 mg $248.29 · 300 mg $925.01Plus $5.25 shipping

From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.

About these prices

Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.

Regular genericMakers and their savings cards

4 companies sell a generic of Thiola EC that the FDA rates a substitute. A pharmacy fills whichever one it stocks. 2 of them have their own savings cards, listed first. Each works only with that maker’s version. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

It’s mostly filled by specialty pharmacies. Your prescriber’s office or insurer can tell you which one to use.

Cycle PharmaceuticalsAll 2 strengths

Has lactose · Sold as Venxxiva · Made by Torrent Pharmaceuticals

Cycle Vita Co-Pay Assistance Program (VENXXIVA tiopronin delayed-release)

For VENXXIVA (tiopronin) delayed-release tablets

With commercial insurance as little as $0

Sign up on cyclevita.life

In the maker’s words
“Commercially insured eligible patients may pay as little as $0.”

How it looks, what’s in it, NDCs

100 mg White to off-white, round, 8 mm, marked “1A”

Package NDC
Bottle of 300 70709-121-30

300 mg White to off-white, round, 11 mm, marked “3A”

Package NDC
Bottle of 90 70709-123-90

Inactive ingredients: lactose monohydrate, hydroxypropyl cellulose, hydroxypropyl cellulose, low substituted, hypromellose, methacrylic acid - ethyl acrylate copolymer (1:1) type a, talc, triethyl citrate, magnesium stearate
FDA label
Teva PharmaceuticalsAll 2 strengths

Has lactose

Teva Tiopronin Tablets savings card

With commercial insurance as little as $0

Print the card (PDF)

Or call 1-844-248-7949. See the offer on tevausa.com

In the maker’s words
“Commercially insured patients may pay as little as $0 out of pocket for Teva’s Tiopronin Tablets.”

Product page on tevausa.com

How it looks, what’s in it, NDCs

100 mg White to off-white, round, 8 mm, marked “R1”

Package NDC
Bottle of 300 0480-9227-55

300 mg White to off-white, round, 11 mm, marked “R3”

Package NDC
Bottle of 90 0480-7824-98

Inactive ingredients: ammonia, ferrosoferric oxide, silicon dioxide, hydroxypropyl cellulose, hypromellose 2910 (6 mpa.s), lactose monohydrate, low-substituted hydroxypropyl cellulose (11% hydroxypropyl; 130000 mw), magnesium stearate, methacrylic acid and ethyl acrylate copolymer, propylene glycol, shellac, talc, triethyl citrate
FDA label
Par HealthAll 2 strengths

Has lactose · Made by PH Health

How it looks, what’s in it, NDCs

100 mg White to off-white, round, 8 mm, marked “D1”

Package NDC
Bottle of 300 0254-3034-30

300 mg White to off-white, round, 11 mm, marked “D3”

Package NDC
Bottle of 90 0254-3035-09

Inactive ingredients: anhydrous lactose, silicon dioxide, hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose (11% hydroxypropyl; 130000 mw), hypromellose, magnesium stearate, methacrylic acid and ethyl acrylate copolymer, talc, triethyl citrate, ammonia, ferric oxide red, propylene glycol, shellac, dimethicone
FDA label
Torrent PharmaceuticalsAll 2 strengths

Has lactose

How it looks, what’s in it, NDCs

100 mg White, round, 8 mm, marked “1A”

Package NDC
Bottle of 300 13668-691-03

300 mg White, round, 11 mm, marked “3A”

Package NDC
Bottle of 90 13668-692-90

Inactive ingredients: lactose monohydrate, hydroxypropyl cellulose, hydroxypropyl cellulose, low substituted, hypromellose, methacrylic acid - ethyl acrylate copolymer (1:1) type a, talc, triethyl citrate, magnesium stearate
FDA label

Package	NDC
Bottle of 300	70709-121-30

Package	NDC
Bottle of 90	70709-123-90

Package	NDC
Bottle of 300	0480-9227-55

Package	NDC
Bottle of 90	0480-7824-98

Package	NDC
Bottle of 300	0254-3034-30

Package	NDC
Bottle of 90	0254-3035-09

Package	NDC
Bottle of 300	13668-691-03

Package	NDC
Bottle of 90	13668-692-90

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

What it’s used for

Preventing cystine kidney stones (cystinuria)

What the FDA label says

THIOLA EC is a reducing and complexing thiol indicated, in combination with high fluid intake, alkali, and diet modification, for the prevention of cystine stone formation in adults and pediatric patients 20 kg and greater with severe homozygous cystinuria, who are not responsive to these measures alone.

Source: the FDA label for Thiola EC (Mission Pharmacal Company), October 7, 2025. Full label on DailyMed

Good to know

It may look different from Thiola EC (color, shape, or markings). That’s normal for an authorized generic.
If your prescription says “dispense as written,” the pharmacy needs your prescriber’s OK to give you the authorized generic.
Cash prices can differ a lot from one pharmacy to the next, so it can pay to ask two. With insurance, what you pay depends on your plan.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/thiola-ec/