Brand-name prescription

Twyneo

benzoyl peroxide and tretinoin

Compare your options

Compare	TwyneoBrand name	Authorized genericWithout the Twyneo name	Regular genericbenzoyl peroxide and tretinoin
What pharmacies pay	$950per 30 g bottle	Not sold	Not sold
Same as Twyneo?	The original	–	–
Ways to save	Maker’s cardas little as $0 a prescriptionwith commercial insurance	–	–
With insurance	Your plan’s brand co-pay	–	–

No authorized generic: There isn’t one.

No regular generic: No generic is sold yet.

Prices are the average U.S. drugstores pay (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

The maker’s savings card

Rx Maker’s savings card Mayne Pharma

Mayne Pharma Patient Savings Card

With commercial insurance

as little as $0 a prescription

Paying cash, no insurance

as little as $45 a prescription

Get it on twyneo.com

In the maker’s words

“Get face-to-face with savings! Download your Mayne Pharma Patient Savings Card, and you could pay as little as $0 with commercial insurance or $45 without insurance.”

From the maker’s offer on twyneo.com, checked September 25, 2026. What you pay depends on your plan. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Before you use a discount card

Discount cards like GoodRx take money off the pharmacy’s cash price. For a brand-name drug, that price is often still high. With commercial insurance, Twyneo’s own card may bring it to as little as $0 a prescription. Paying cash, the maker’s own price is as little as $45 a prescription.

Look up the discount-card price, then compare it with this estimate. You can use a maker’s card or a discount card, but usually not both on the same fill.

What pharmacies pay

The average U.S. drugstores pay for each strength (source: Medicaid, September 23, 2026). What you pay depends on your plan or the pharmacy.

Strength	Twyneo
0.1%-3% cream pumpper 30 g bottle	$950

Good to know

There’s no authorized generic of Twyneo.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.