Twyneo savings card: as little as $45 a prescription without insurance

How to pay the least

Lowest posted price

as little as $45 a prescription

Twyneo from Mayne Pharma, without insurance.

No generic is sold yet.

Compare every option

Brand nameTwyneo

Authorized genericbenzoyl peroxide and tretinoin

Regular genericbenzoyl peroxide and tretinoin

What you’d pay

As little as$45a prescription with the maker’s card

Not soldThere isn’t one

Not soldNone sold yet

Same as Twyneo?

The original

–

Brand nameThe maker’s card

Mayne Pharma Patient Savings Card

Savings card from Mayne Pharma

No insurance · as little as $45 a prescription

Insurance · as little as $0 a prescription

In the maker’s words

“Get face-to-face with savings! Download your Mayne Pharma Patient Savings Card, and you could pay as little as $0 with commercial insurance or $45 without insurance.”

From the maker’s offer on twyneo.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Maker’s card or discount card?

A discount card like GoodRx lowers the pharmacy’s cash price, but for a brand-name drug that price often stays high. Compare it with the maker’s price above. You can usually use one or the other on a fill, not both.

Authorized genericNot sold

There isn’t one. An authorized generic is Twyneo itself, from the same company, sold without the brand name, and usually for less. For now Twyneo is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

No generic is sold yet. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Acne

What the FDA label says

TWYNEO is a combination tretinoin, a retinoid, and benzoyl peroxide indicated for the topical treatment of acne vulgaris in adults and pediatric patients 9 years of age and older.

Source: the FDA label for Twyneo (Mayne Pharma Commercial LLC), August 11, 2025. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/twyneo/