How do you pay?

How to pay the least

Ask for the cash price

Generic estradiol

No pharmacy we check posts a price for it.

  1. Ask your pharmacy for the cash price of generic estradiol.Find pharmacies near you 
  2. Ask one or two other pharmacies too. Cash prices for the same generic can differ a lot from store to store.

A regular generic has the same active ingredient as Vagifem, and the FDA requires it to work the same way.

Compare every option

Question
Brand nameVagifem
Authorized genericestradiol
Regular genericestradiol
What you’d pay
Cash priceAsk the pharmacyUsually the highest price
Not soldThere isn’t one
Cash priceAsk the pharmacyUsually the lowest
Same as Vagifem?
The original
–
Same active ingredientFillers and dyes can differ

Brand nameNo maker’s card

We didn’t find a savings card or cash price from Vagifem’s maker. Ask the pharmacy for Vagifem’s cash price. With insurance, ask what your plan charges.

Authorized genericNot sold

There isn’t one. An authorized generic is Vagifem itself, from the same company, sold without the brand name, and usually for less. A regular generic is sold, with the same active ingredient: ask the pharmacy for its price.

See the regular generic →

Regular genericWho makes it

5 companies sell a generic of Vagifem that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.

  • Amneal PharmaceuticalsTablet 10 mcg

    Has lactose · Sold as Yuvafem

    How it looks, what’s in it, NDCs

    10 mcg White, round, 6 mm, marked “AN / 276”

    PackageNDC
    Carton of 865162-226-21
    Carton of 1865162-226-23

    Inactive ingredients: hypromelloses, lactose monohydrate, starch, corn, magnesium stearate, polyethylene glycol

    FDA label

  • Aurobindo PharmaTablet 10 mcg

    Has lactose · Sold as Estradiol Vaginal Inserts

    Product page on aurobindousa.com

    How it looks, what’s in it, NDCs

    10 mcg White to off-white, round, 6 mm, marked “S / 10”

    PackageNDC
    Carton of 859651-439-08
    Carton of 1859651-439-18

    Inactive ingredients: starch, corn, hypromellose 2910 (15 mpa.s), hypromellose 2208 (100 mpa.s), lactose monohydrate, magnesium stearate

    FDA label

  • Glenmark PharmaceuticalsTablet 10 mcg

    Has lactose · Sold as Estradiol Vaginal Inserts

    Product page on glenmarkpharma-us.com

    How it looks, what’s in it, NDCs

    10 mcg White to off-white, round, 6 mm, marked “G / 94”

    PackageNDC
    Carton of 868462-711-71
    Carton of 1868462-711-88

    Inactive ingredients: silicon dioxide, starch, corn, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol

    FDA label

  • NorthStar RxTablet 10 mcg

    Has lactose · Sold as Estradiol Vaginal Inserts · Made by Aurobindo Pharma

    Product page on northstarrxllc.com

    How it looks, what’s in it, NDCs

    10 mcg White to off-white, round, 6 mm, marked “S / 10”

    PackageNDC
    Carton of 872603-874-08
    Carton of 1872603-874-18

    Inactive ingredients: starch, corn, hypromellose 2910 (15 mpa.s), hypromellose 2208 (100 mpa.s), lactose monohydrate, magnesium stearate

    FDA label

  • Teva PharmaceuticalsInsert 10 mcg

    Has lactose

    How it looks, what’s in it, NDCs

    10 mcg White to off-white, marked “TV / T5”

    PackageNDC
    Carton of 80093-3223-08
    Carton of 180093-3223-97

    Inactive ingredients: starch, corn, hypromellose 2208 (100 mpa.s), hypromellose 2910 (15 mpa.s), lactose monohydrate, magnesium stearate, polyethylene glycol 6000

    FDA label

Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.

What to say at the pharmacy

“Before you fill my Vagifem, can you tell me what I’d pay for the brand and for a generic?”

Paying cash? Ask for each one’s cash price. With insurance, ask what your plan charges for each.

What it’s used for

What the FDA label says
  • Vagifem is an estrogen indicated for the treatment of atrophic vaginitis due to menopause.

Source: the FDA label for Vagifem (Novo Nordisk), February 10, 2025. Full label on DailyMed 

Good to know