Vyloy savings card: as little as $5 a dose with commercial insurance

Vyloy is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

How to pay the least

Given by your care team

Billed by the clinic

Vyloy is given by a doctor or nurse, not picked up at a pharmacy.

Ask your care team or your plan what you’d pay before your visit.

Compare every option

Brand nameVyloy

Authorized genericzolbetuximab

Regular genericzolbetuximab

What you’d pay

Cash priceAsk the pharmacy

Not soldThere isn’t one

Not soldAsk the pharmacy

Same as Vyloy?

The original

–

Brand nameThe maker’s card

VYLOY Copay Assistance Program

Savings card from Astellas

No insuranceNeeds insuranceNo cash price listed.

Insurance · as little as $5 a dose

The card takes up to $25,000 a year off your co-pay.

Or call 1-855-272-6609.

In the maker’s words

“which allows eligible patients to pay as little as $5 per dose.”

From the maker’s offer on vyloysupportsolutions.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericNot sold

There isn’t one. An authorized generic is Vyloy itself, from the same company, sold without the brand name, and usually for less. For now Vyloy is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

Vyloy is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

Claudin 18.2-positive stomach or gastroesophageal junction cancer

What the FDA label says

VYLOY is a claudin 18.2-directed cytolytic antibody and is indicated in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adults with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastroesophageal junction adenocarcinoma whose tumors are claudin (CLDN) 18.2 positive as determined by an FDA-approved test.

Source: the FDA label for Vyloy (Astellas Pharma US, Inc.), August 11, 2026. Full label on DailyMed

Good to know

“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to the clinic’s billing office.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.

Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/vyloy/