Brand-name prescription

Xiaflex

collagenase clostridium histolyticum

Compare your options

Compare	XiaflexBrand name	Authorized genericWithout the Xiaflex name	Regular genericcollagenase clostridium histolyticum
What pharmacies pay	–	Not sold	Not sold
Same as Xiaflex?	The original	–	–
Ways to save	Maker’s card$0 a vialwith commercial insurance	–	–
With insurance	Your plan’s brand co-pay	–	–

No authorized generic: There isn’t one.

No regular generic: Xiaflex is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold.

Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

The maker’s savings card

Rx Maker’s savings card Keenova Therapeutics (formerly Endo)

XIAFLEX Copay Assistance Program (Zero Pay Program)

With commercial insurance

$0 a vial

No insurance

This card needs commercial insurance. The maker doesn’t list a cash price on this page.

Get it on peyronies-disease.xiaflex.com

In the maker’s words

“Most eligible patients with commercial insurance plans should pay a $0 copay for XIAFLEX.”

From the maker’s offer on peyronies-disease.xiaflex.com, checked September 25, 2026. What you pay depends on your plan. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Before you use a discount card

Discount cards like GoodRx take money off the pharmacy’s cash price. For a brand-name drug, that price is often still high. With commercial insurance, Xiaflex’s own card may bring it to $0 a vial.

Look up the discount-card price, then compare it with this estimate. You can use a maker’s card or a discount card, but usually not both on the same fill.

Good to know

There’s no authorized generic of Xiaflex.
“Commercial insurance” means a plan from a job, from the marketplace, or one you buy yourself. A retiree plan that’s part of Medicare counts as Medicare. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.
Most cards need a sign-up on the maker’s site, and many work only if your plan covers the drug. Then give the card’s details to your pharmacy.
Don’t stop or change a medicine without talking to your pharmacist or prescriber.