An authorized generic of Zaroxolyn was sold before, but it isn’t sold now. Ask your pharmacist whether a regular generic (metolazone) is available.
Source: FDA, updated October 30, 2026
How to pay the least
From
$12.67 for 30 tablets delivered ($7.42 plus $5.25 shipping)
Generic metolazone from Cost Plus Drugs, by mail. Pick the strength on your label above for its own price.
- Make a free account on costplusdrugs.com. Ask your prescriber to send the prescription there, or Cost Plus Drugs can transfer it.Open Cost Plus Drugs
- Order generic metolazone. It comes by mail.
Need it today? From $15.08 for 30 tablets with the free Team Cuban Card, at pharmacies that take it. Get the free card and show it there.
See the price and get the cardA regular generic has the same active ingredient as Zaroxolyn, and the FDA requires it to work the same way.
Compare every option
Question
Brand nameZaroxolyn
Authorized genericmetolazone
Regular genericmetolazone
What you’d pay
Not soldNo longer sold
Not soldNo longer sold
Same as Zaroxolyn?
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–
Same active ingredientFillers and dyes can differ
Details for each option
Details for
Brand nameNot sold
Zaroxolyn itself isn’t sold as a prescription anymore. Its generic versions, if any, are in the other tabs.
Authorized genericNot sold now
Regular genericWhere to buy it
Pharmacies’ own cash prices for generic metolazone, lowest first.
Pick up in storeDelivered
- Delivered: Cost Plus Drugs from $7.42for 30 tablets2.5 mg $7.42 · 5 mg $7.86 · 10 mg $11.11Plus $5.25 shipping
- Delivered: Rx Outreach $15for 30 tablets2.5 mg, 5 mgeach additional 30 tablets: $3Free delivery
- Pick up in store: Team Cuban Card from $15.08for 30 tablets2.5 mg $15.08 · 5 mg $16.01 · 10 mg $17.94Free card · Kroger, Albertsons, Safeway, Meijer and many local pharmaciesFind a pharmacy that takes it
- Delivered: Amazon Pharmacy from $15.50for 30 tablets2.5 mg $15.50 · 5 mg $17.60 · 10 mg $21.20Prime members only · $139 a year · Free delivery · Prime price: limits on some medicines if you're over 65 or have Medicare, Medicaid or TRICARE
- Pick up in store: Costco $17.99for 30 tablets2.5 mgMembers only · $65 a yearFind the nearest store
- Delivered: Costco $17.99for 30 tablets2.5 mgMembers only · $65 a year · Plus shipping
- Pick up in store: Walgreens + Optum Perks $21.76for 30 tablets2.5 mgFree Optum Perks coupon · not with insuranceFind the nearest store
- Pick up in store: Target (CVS) + Optum Perks $23.26for 30 tablets2.5 mgFree Optum Perks coupon · not with insuranceFind the nearest store
- Pick up in store: Sam's Club See its pricePlus members only · $120 a yearFind the nearest store
From each pharmacy’s own site, read November 2, 2026. Confirm the price before you fill.
About these prices
Prices change, can differ by store and state, and may depend on the strength and how many you take. With insurance, ask what your plan charges; it can be less.
Regular genericWho makes it
9 companies sell a generic of Zaroxolyn that the FDA rates a substitute. A pharmacy fills whichever one it stocks. To get a certain maker, ask for it by name; most pharmacies can order it in a day or two.
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Advagen Pharma2.5 mg, 5 mg, 10 mg
Has a dye: D&C Yellow No. 10 aluminum lake · Made by Rubicon Research
How it looks, what’s in it, NDCs
2.5 mg White to off white, round, 5 mm, marked “17 / UpArrowhead”
Package NDC Bottle of 100 72888-052-01 5 mg White to off white, round, 6 mm, marked “25 / UpArrowhead”
Package NDC Bottle of 100 72888-053-01 10 mg Pale yellow to yellow, round, 6 mm, marked “27 / UpArrowhead”
Package NDC Bottle of 100 72888-054-01 Inactive ingredients: magnesium stearate, cellulose, microcrystalline, silicon dioxide, D&C Yellow No. 10 aluminum lake
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Alembic Pharmaceuticals2.5 mg, 5 mg, 10 mg
Has dyes: D&C Red No. 27, FD&C Blue No. 2, D&C Yellow No. 10, FD&C Yellow No. 6
How it looks, what’s in it, NDCs
2.5 mg Pink, round, 6 mm, marked “L48”
Package NDC Bottle of 100 62332-532-31 Bottle of 1000 62332-532-91 5 mg Blue, round, 6 mm, marked “L49”
Package NDC Bottle of 100 62332-533-31 Bottle of 1000 62332-533-91 10 mg Yellow, round, 6 mm, marked “L50”
Package NDC Bottle of 100 62332-534-31 Bottle of 1000 62332-534-91 Inactive ingredients: microcrystalline cellulose, magnesium stearate, D&C Red No. 27, FD&C Blue No. 2, D&C Yellow No. 10, FD&C Yellow No. 6
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Amici Pharma2.5 mg, 5 mg, 10 mg
Has dyes: FD&C Yellow No. 6, D&C Red No. 30 · Made by Innogenix
How it looks, what’s in it, NDCs
2.5 mg PEACH, round, 6 mm, marked “I121”
Package NDC Bottle of 100 69292-562-01 Bottle of 1000 69292-562-10 5 mg Pink, round, 6 mm, marked “I122”
Package NDC Bottle of 100 69292-564-01 Bottle of 1000 69292-564-10 10 mg Orange, round, 6 mm, marked “I123”
Package NDC Bottle of 100 69292-566-01 Bottle of 1000 69292-566-10 Inactive ingredients: silicon dioxide, magnesium stearate, cellulose, microcrystalline, FD&C Yellow No. 6, D&C Red No. 30
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Ingenus Pharmaceuticals2.5 mg, 5 mg, 10 mg
Made by Renata
Packages and NDCs
2.5 mg Pink, round, 6 mm, marked “ZNM / 2 / 1 / 2”
Package NDC Bottle of 100 50742-349-01 5 mg White to off White, round, 6 mm, marked “ZNM / 5”
Package NDC Bottle of 100 50742-350-01 10 mg Pale Yellow to Yellow, round, 6 mm, marked “ZNM / 10”
Package NDC Bottle of 100 50742-351-01 -
Method Pharmaceuticals2.5 mg, 5 mg, 10 mg
Has dyes: FD&C Yellow No. 6, D&C Red No. 30 · Made by Innogenix
How it looks, what’s in it, NDCs
2.5 mg PEACH, round, 6 mm, marked “I121”
Package NDC Bottle of 100 58657-740-01 Bottle of 1000 58657-740-10 2.5 mg PEACH, round, 6 mm, marked “I121”
Package NDC Carton of 100 58657-940-01 5 mg Pink, round, 6 mm, marked “I122”
Package NDC Bottle of 100 58657-741-01 Bottle of 1000 58657-741-10 5 mg Pink, round, 6 mm, marked “I122”
Package NDC Carton of 100 58657-941-01 10 mg Orange, round, 6 mm, marked “I123”
Package NDC Bottle of 100 58657-742-01 Bottle of 1000 58657-742-10 10 mg Orange, round, 6 mm, marked “I123”
Package NDC Carton of 100 58657-942-01 Inactive ingredients: silicon dioxide, magnesium stearate, cellulose, microcrystalline, FD&C Yellow No. 6, D&C Red No. 30
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Mylan Institutional2.5 mg, 5 mg
Has a dye: FD&C Yellow No. 6
How it looks, what’s in it, NDCs
2.5 mg Peach, round, 6 mm, marked “M / 172”
Package NDC Carton of 100 51079-023-20 5 mg Orange, round, 6 mm, marked “M / 173”
Package NDC Carton of 100 51079-024-20 Inactive ingredients: silicon dioxide, FD&C Yellow No. 6, magnesium stearate, microcrystalline cellulose
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Mylan Pharmaceuticals2.5 mg, 5 mg, 10 mg
Has dyes: FD&C Yellow No. 6, D&C Yellow No. 10, FD&C Blue No. 2
How it looks, what’s in it, NDCs
2.5 mg Peach, round, 6 mm, marked “M / 172”
Package NDC Bottle of 100 0378-6172-01 5 mg Orange, round, 6 mm, marked “M / 173”
Package NDC Bottle of 100 0378-6173-01 10 mg Light green, round, 6 mm, marked “M / 174”
Package NDC Bottle of 100 0378-6174-01 Inactive ingredients: silicon dioxide, FD&C Yellow No. 6, magnesium stearate, microcrystalline cellulose, D&C Yellow No. 10, FD&C Blue No. 2
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Sandoz2.5 mg, 5 mg, 10 mg
Has dyes: D&C Red No. 30, FD&C Blue No. 2, D&C Yellow No. 10, FD&C Yellow No. 6
How it looks, what’s in it, NDCs
2.5 mg Pink, oval, 6 mm, marked “E50”
Package NDC Bottle of 100 0185-5050-01 Bottle of 1000 0185-5050-10 5 mg Blue, oval, 6 mm, marked “E55”
Package NDC Bottle of 100 0185-0055-01 Bottle of 1000 0185-0055-10 10 mg Yellow, oval, 6 mm, marked “E56”
Package NDC Bottle of 100 0185-5600-01 Bottle of 1000 0185-5600-10 Inactive ingredients: microcrystalline cellulose, D&C Red No. 30, FD&C Blue No. 2, magnesium stearate, silicon dioxide, D&C Yellow No. 10, FD&C Yellow No. 6
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Unichem Pharmaceuticals2.5 mg, 5 mg, 10 mg
Has dyes: D&C Red No. 30, FD&C Blue No. 2, D&C Yellow No. 10, FD&C Yellow No. 6
Product page on unichemusa.com
How it looks, what’s in it, NDCs
2.5 mg Pink, round, 6 mm, marked “M / 2 / 5”
Package NDC Bottle of 100 76385-136-01 5 mg Blue, round, 6 mm, marked “M / 5”
Package NDC Bottle of 100 76385-137-01 10 mg Yellow, round, 6 mm, marked “M / 10”
Package NDC Bottle of 100 76385-138-01 Inactive ingredients: microcrystalline cellulose 102, magnesium stearate, silicon dioxide, D&C Red No. 30, FD&C Blue No. 2, D&C Yellow No. 10, FD&C Yellow No. 6
Who sells it: FDA and Medicaid records, updated weekly. Each maker’s page, card and program is from its own site.
What it’s used for
What the FDA label says
Metolazone tablets, USP, are indicated for the treatment of salt and water retention including:
- edema accompanying congestive heart failure;
- edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.
Metolazone tablets, USP, are also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class. MYKROX Tablets, a more rapidly available form of metolazone, are intended for the treatment of new patients with mild to moderate hypertension. A dose titration is necessary if MYKROX Tablets are to be substituted for metolazone tablets, USP, in the treatment of hypertension. See package circular for MYKROX Tablets.
Usage In Pregnancy
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Metolazone tablets, USP, are indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (see PRECAUTIONS). Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may be appropriate.
Source: the FDA label for Metolazone (Method Pharmaceuticals, LLC), February 11, 2026. Full label on DailyMed
Prices checked November 2, 2026. Prices change: confirm with the pharmacy before you fill. drugalt.com/drug/zaroxolyn/