Ziihera is given by a doctor or nurse and billed by the clinic, not a pharmacy. Your care team and your insurance decide which product you get, so ask them what you’d pay.

How do you pay?

How to pay the least

Given by your care team

Billed by the clinic

Ziihera is given by a doctor or nurse, not picked up at a pharmacy.

  1. Ask your care team or your plan what you’d pay before your visit.

Compare every option

Question
Brand nameZiihera
Authorized genericzanidatamab-hrii
Regular genericzanidatamab-hrii
What you’d pay
Cash priceAsk the pharmacy
Not soldThere isn’t one
Not soldAsk the pharmacy
Same as Ziihera?
The original
–
–

Brand nameThe maker’s card

ZIIHERA Savings Card (JazzCares)

Savings card from Jazz Pharmaceuticals

No insuranceNeeds insuranceNo cash price listed.
Insurance · as little as $0 a prescription

Sign up on jazzcares.com 

Or call 1-833-533-5299.

In the maker’s words

“Savings Card—If you are eligible and commercially insured, you may pay as little as $0 per prescription, subject to an annual maximum…”

From the maker’s offer on jazzcares.com, checked November 2, 2026. Co-pay cards can’t be used with Medicare (including Medicare Advantage), Medicaid, TRICARE or VA.

Authorized genericNot sold

There isn’t one. An authorized generic is Ziihera itself, from the same company, sold without the brand name, and usually for less. For now Ziihera is the only choice; its maker’s savings card can lower what you pay.

See the brand name →

Regular genericNot sold

Ziihera is a biologic. Biologics don’t have generics, but some have biosimilars or an unbranded version from the same maker. Ask your pharmacist or prescriber whether one is sold. Generics usually come once the brand’s patents and exclusivity end. Until then, the maker’s savings card is the way to pay less.

See the brand name →

What it’s used for

What the FDA label says

ZIIHERA is a bispecific HER2-directed antibody indicated for:

Gastroesophageal Adenocarcinoma (GEA)

  • in combination with fluoropyrimidine- and platinum-containing chemotherapy, and tislelizumab-jsgr, as first-line treatment of adult patients with HER2-positive (IHC 3+ or IHC 2+/ISH+) unresectable locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma, as detected by an FDA-authorized test.
  • in combination with fluoropyrimidine- and platinum-containing chemotherapy, as first-line treatment of adult patients with HER2-positive (IHC 3+) unresectable locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma, as detected by an FDA-authorized test.

Biliary Tract Cancer (BTC)

  • for the treatment of adults with previously treated, unresectable or metastatic HER2-positive (IHC 3+) BTC, as detected by an FDA-authorized test.*
  • This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).

Source: the FDA label for Ziihera (Jazz Pharmaceuticals, Inc.), August 24, 2026. Full label on DailyMed 

Good to know